A Study of BMS-986490 With or Without Bevacizumab in Advanced Solid Tumors

Part of paid clinical trials in Los Angeles, California.

Sponsor
Bristol-Myers Squibb
Study ID
NCT06730750
Phase
PHASE1/PHASE2
Status
Recruiting
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Conditions

  • Advanced Solid Tumors

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • BMS-986490 — DRUG
    Specified dose on specified days.
  • Bevacizumab — DRUG
    Specified dose on specified days.

Study Details

This is a study of BMS-986490 as a monotherapy and in combination with bevacizumab in participants with select advanced solid tumors known to express CEACAM5.

Key Dates

Start date
Feb 12, 2025
Status verified
Dec 2025
Primary completion
Sep 5, 2026
Completion
Dec 9, 2029

Study Design

Enrollment
360 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: Part 1A
  • Experimental: Part 2A - Colorectal Cancer (CRC)
  • Experimental: Part 2A - Non-Small Cell Lung Cancer/Gastric Cancer (NSCLC/GC)
  • Experimental: Part 1B
  • Experimental: Part 2B

Primary Outcome Measure

Number of participnats with Adverse Events (AEs) [ Time Frame: Up to 100 days following discontinuation of dosing ]

Central Contacts

  • BMS Clinical Trials Contact Center www.BMSClinicalTrials.com
    855-907-3286
    [email protected]
  • First line of the email MUST contain the NCT# and Site #.

Locations (4)

FacilityCityStateZIPSite coordinators
USC/Norris Comprehensive Cancer CenterLos AngelesCalifornia90033
Heinz-Josef Lenz, Site 0007
323-865-3967
START MidwestGrand RapidsMichigan49546
Nehal Lakhani, Site 0017
616-954-5554
John Theurer Cancer Center at Hackensack University Medical CenterHackensackNew Jersey07601
Martin Gutierrez, Site 0004
551-996-5863
UPMC Hillman Cancer CenterPittsburghPennsylvania15232
Anwaar Saeed, Site 0006
816-898-9413

Find similar trials in Los Angeles, CA

By research site
USC/Norris Comprehensive Cancer Center· Los Angeles, CASTART Midwest· Grand Rapids, MIJohn Theurer Cancer Center at Hackensack University Medical Center· Hackensack, NJUPMC Hillman Cancer Center· Pittsburgh, PA

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