A Comparison of Renal vs Limb NIRS for Predicting Cardiac Surgery Associated Acute Kidney Injury

Part of paid clinical trials in Salt Lake City, Utah.

Sponsor
University of Utah
Study ID
NCT06705855
Status
Recruiting
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Conditions

  • AKI - Acute Kidney Injury
  • Cardiac Surgery Associated - Acute Kidney Injury
  • Cardiac Surgery Requiring Cardiopulmonary Bypass
  • NIRS

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • NIRS sensor placement — DEVICE
    After written informed consent, the patient will be brought to the operating room. Skin tone will be assessed using the Monk scale. Prior to induction of general anesthesia, the right kidney will be located by surface ultrasound, the distance between the renal capsule and the skin will be measured, and a NIRS sensor will be placed on the skin overlaying the kidney. If the patient has had a right nephrectomy, the left kidney will be used. Additional NIRS sensors will then be placed over the patient's ipsilateral biceps and vastus lateralis muscles. The distance from the skin to the muscle tissue will be measured and recorded using ultrasound. NIRS sensors will also be placed on the patient's forehead to measure cerebral oximetry as is current practice at our institution for all cardiac surgeries requiring cardiopulmonary bypass.

Study Details

Acute kidney injury (AKI) is a complication of cardiac surgery that can affect outcome. Near Infrared Spectroscopy (NIRS) is a technology that uses light to determine how well oxygenated tissues are. This technology is routinely used in cardiac surgery to measure the oxygen level in the brain by placing a sensor sticker on the forehead. The purpose of the study is to determine whether NIRS sensor stickers placed on the skin over the kidney can predict AKI better than when sensors are placed on the skin over the participant's limbs. This study is being conducted by investigators from the department of anesthesiology at the University of Utah.

Key Dates

Start date
May 29, 2025
Status verified
Jul 2025
Primary completion
May 30, 2026
Completion
Aug 30, 2026

Study Design

Enrollment
100 participants (estimated)

Arms

  • Arm: Adult cardiac surgery patients undergoing cardiopulmonary bypass surgery at risk for AKI
    We will enroll a convenience sample of adult cardiac surgery patients undergoing procedures that require cardiopulmonary bypass (CPB) and who are at risk for AKI.

Primary Outcome Measure

Development of post-operative acute kidney injury (AKI) in adult cardiac surgery patients [ Time Frame: From post-operative day 0 to post-operative day 7(KDIGO stage I AKI) ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
University of UtahSalt Lake CityUtah84132
Natalie Silverton, MD
[email protected]
801-581-6393

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By research site
University of Utah· Salt Lake City, UT

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