Nitrous Oxide Neuroimaging

Part of paid clinical trials in Pittsburgh, Pennsylvania.

Sponsor
Keith M Vogt
Study ID
NCT06702631
Phase
EARLY_PHASE1
Status
Recruiting
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Conditions

  • Amnesia
  • Anesthesia
  • Pain

Eligibility Criteria

Sex
ALL
Age
18 Years - 59 Years
Healthy Volunteers
Accepted

Interventions

  • Nitrous oxide — DRUG
    After a no-drug control period, subjects will inhale nitrous oxide, administered via a breathing circuit and face mask, until a steady-state target end-tidal expired concentration is reached. During the drug condition, subjects will receive low-dose nitrous oxide (% corresponding to Minimum Alveolar Concentration).
  • Peripheral Nerve Stimulation — DEVICE
    Experimental acute pain stimulus will be delivered using a nerve stimulator. These painful shocks will be paired with a fixed number of the experimental cues, in a pattern that appears random to participants.

Study Details

The purpose of this study is to determine the effects of acute pain on long-term memory and conditioned physiologic responses in the presence and absence of low dose nitrous oxide. Functional magnetic resonance imaging will be used to identify the neural correlates of these phenomena. The study will occur over 2 visits and involves no long-term follow up.

Key Dates

Start date
Jan 13, 2025
Status verified
Jun 2026
Primary completion
Sep 1, 2026
Completion
Sep 1, 2026

Study Design

Enrollment
60 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: Nitrous Oxide + Pain
    Single-arm study. All subjects receive nitrous oxide and painful electric nerve stimulation, as described in the interventions.

Primary Outcome Measure

Brain activation to painful stimulation difference: Drug-free condition minus nitrous oxide condition [ Time Frame: Visit 1: Immediate; average activity, calculated from each task scan ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
University of PittsburghPittsburghPennsylvania15213-

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By research site
University of Pittsburgh· Pittsburgh, PA

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