White Matter Plasticity in Schizophrenia

Part of paid clinical trials in Catonsville, Maryland.

Sponsor
University of Maryland, Baltimore
Study ID
NCT06641297
Status
Recruiting
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Conditions

  • Schizophrenia Disorders

Eligibility Criteria

Sex
ALL
Age
15 Years - 45 Years
Healthy Volunteers
Not accepted

Interventions

  • Music video game — BEHAVIORAL
    The video game \'Guitar Hero\' will be used as the platform for training for participants to acquire a new \'skill\'

Study Details

Schizophrenia spectrum disorders are associated with impairment in the microstructure of white matter, the key brain tissue responsible for fast communication between different brain regions necessary for any complex task. This white matter impairment is linked to problems with cognition in schizophrenia, especially slower processing speed. This project aims to study the potential for correcting white matter deficits in schizophrenia by examining mechanisms underlying white matter structure changes in response to training on playing a mock musical instrument.

Key Dates

Start date
Jan 2, 2025
Status verified
Feb 2026
Primary completion
Dec 31, 2026
Completion
Dec 31, 2026

Study Design

Enrollment
36 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE

Arms

  • Active Comparator: Active training
    Training sessions involving playing the video game 'Guitar Hero'
  • Placebo Comparator: Observation training

Primary Outcome Measure

White matter microstructure [ Time Frame: 3 weeks ]

Central Contacts

Locations (2)

FacilityCityStateZIPSite coordinators
Maryland Psychiatric Research CenterCatonsvilleMaryland21228
Joshua Chiappelli, MD
[email protected]
410-402-6827
University of Maryland Baltimore - Maryland Psychiatric Research CenterCatonsvilleMaryland21228
Joshua J Chiappelli, MD
[email protected]
410-402-6827

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By research site
Maryland Psychiatric Research Center· Catonsville, MDUniversity of Maryland Baltimore - Maryland Psychiatric Research Center· Catonsville, MD

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