FIT Exercise in 30d of ULLS-induced Muscle Disuse

Part of paid clinical trials in Lexington, Kentucky.

Sponsor
Lance Bollinger
Study ID
NCT06631053
Status
Recruiting
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Conditions

  • Muscle Atrophy
  • Muscle Weakness

Eligibility Criteria

Sex
ALL
Age
35 Years - 45 Years
Healthy Volunteers
Accepted

Interventions

  • velocity-based FIT (VBFIT) — OTHER
    Participants will ambulate unilaterally using a shoe modified with a 5cm rocker-style stack and forearm crutches for the duration of the study. All participants will complete two testing sessions prior to ULLS, one testing session at day 13, and two testing sessions at the end of the study. Those assigned to the exercise group will perform a both high-intensity resistance and aerobic exercise three times per week
  • No Exercise — OTHER
    Participants will ambulate unilaterally using a shoe modified with a 5cm rocker-style stack and forearm crutches for the duration of the study. All participants will complete two testing sessions prior to ULLS, one testing session at day 13, and two testing sessions at the end of the study.

Study Details

This study aims to determine how flywheel-based inertial training (FIT) implemented according to principles of velocity-based training (VBT) and High-Intensity Interval Training (HIIT) affects disuse-induced physical de-conditioning including loss of voluntary muscle strength, aerobic capacity, and balance regulation.

Key Dates

Start date
Oct 23, 2024
Status verified
Sep 2025
Primary completion
Sep 1, 2026
Completion
Sep 1, 2026

Study Design

Enrollment
16 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Active Comparator: No Exercise
    Participants will undergo a 30d Unilateral Lower Limb Suspension (ULLS) without exercise
  • Experimental: velocity-based FIT (VBFIT)
    Participants will undergo a 30d Unilateral Lower Limb Suspension (ULLS) with exercise

Primary Outcome Measure

Voluntary activation [ Time Frame: Baseline, day 13, and day 30 ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
University of KentuckyLexingtonKentucky40506-

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By research site
University of Kentucky· Lexington, KY

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