Brain Blood Vessel Responses to Changes in Blood Flow: Younger Cohort

Part of paid clinical trials in Madison, Wisconsin.

Sponsor
University of Wisconsin, Madison
Study ID
NCT06629090
Phase
PHASE2
Status
Recruiting
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Conditions

  • Cerebrovascular Circulation
  • Magnetic Resonance Imaging

Eligibility Criteria

Sex
ALL
Age
20 Years - 40 Years
Healthy Volunteers
Accepted

Interventions

  • MRI — DEVICE
    Participants will undergo an MRI scan while performing breathing and simulated postural change tasks.
  • Prazosin — DRUG
    A dose of prazosin will be administered based on body weight
  • Placebo — DRUG
    Oral placebo

Study Details

Brain blood flow will be measured during a simulated postural change test and while breathing increased levels of carbon dioxide using magnetic resonance imaging.

Key Dates

Start date
Dec 17, 2025
Status verified
Dec 2025
Primary completion
Dec 31, 2026
Completion
Dec 31, 2026

Study Design

Enrollment
36 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: Young Adults
    Young Adults between 20-40 years of age.

Primary Outcome Measure

Change in blood velocity [ Time Frame: Two study visits, up to 240 minutes ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
University of WisconsinMadisonWisconsin53705
Anna J Howery, MS
[email protected]
608-262-9572
Jill N Barnes, PhD (PRINCIPAL_INVESTIGATOR)

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By research site
University of Wisconsin· Madison, WI

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