Brain Blood Vessel Responses to Changes in Blood Flow

Part of paid clinical trials in Madison, Wisconsin.

Sponsor
University of Wisconsin, Madison
Study ID
NCT06629077
Phase
PHASE2
Status
Recruiting
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Conditions

  • Cerebrovascular Circulation
  • Magnetic Resonance Imaging

Eligibility Criteria

Sex
ALL
Age
55 Years - 69 Years
Healthy Volunteers
Accepted

Interventions

  • MRI — DEVICE
    Participants will undergo an MRI scan while performing breathing and a simulated postural change task.
  • Prazosin — DRUG
    A dose of prazosin will be administered based on body weight.
  • Placebo — DRUG
    Oral placebo

Study Details

Brain blood flow will be measured during a simulated postural change test and while breathing increased levels of carbon dioxide using magnetic resonance imaging.

Key Dates

Start date
Feb 26, 2026
Status verified
Feb 2026
Primary completion
Jan 31, 2027
Completion
Jan 31, 2027

Study Design

Enrollment
36 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: Middle-Aged Adults
    Middle-Aged Adults between 55-69 years of age.

Primary Outcome Measure

Change in blood flow [ Time Frame: Two study visits, up to 240 minutes ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
University of WisconsinMadisonWisconsin53705
Anna J Howery, MS
[email protected]
608-262-9572
Jill N Barnes, PhD (PRINCIPAL_INVESTIGATOR)

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By research site
University of Wisconsin· Madison, WI

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