Ventilator Mode and Respiratory Physiology

Part of paid clinical trials in La Jolla, California.

Sponsor
University of California, San Diego
Study ID
NCT06624254
Status
Enrolling By Invitation

Conditions

  • Breathing Mechanics
  • Pulmonary Disease
  • Respiratory Effort
  • Respiratory Failure

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • lung mechanics, respiratory drive and effort — OTHER
    Patient lung mechanics and respiratory drive and effort will be measured

Study Details

Modern intensive care units (ICUs) are increasingly adopting newer modes of mechanical ventilation such as adaptive pressure control (APC) modes but there are limited data available regarding risks and benefits of newer modes versus traditional ventilation modes. APC can inadvertently deliver high tidal volumes, which maybe harmful. High tidal volumes may be unrecognized by the provider, due to the complexities of ventilator algorithms and patient interactions. The objective of this aim is to identify risk factors for excess tidal volumes in patients on adaptive pressure control.

Key Dates

Start date
Sep 21, 2024
Status verified
Sep 2024
Primary completion
Sep 30, 2029
Completion
Sep 30, 2029

Study Design

Enrollment
60 participants (estimated)

Arms

  • Arm: Adaptive Pressure Control
    On adaptive pressure control mode with acute respiratory failure

Primary Outcome Measure

Excess tidal volume [ Time Frame: From enrollment to end of monitoring at 4 hours ]

Locations (1)

FacilityCityStateZIPSite coordinators
University of California San Diego HealthLa JollaCalifornia92037-

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