Mechanisms of Anabolic Resistance in Older Humans

Part of paid clinical trials in Rochester, Minnesota.

Sponsor
Mayo Clinic
Study ID
NCT06617195
Status
Recruiting
Apply to this trial

Conditions

  • Aging

Eligibility Criteria

Sex
ALL
Age
21 Years - 85 Years
Healthy Volunteers
Accepted

Interventions

  • Exercise — OTHER
    Young and older adults will perform a single bout of unaccustomed resistance exercise to evaluate molecular and cellular response in skeletal muscle

Study Details

The purpose of this research is to understand how chronic inflammation affects muscle function and responses to exercise in older adults.

Key Dates

Start date
Jan 14, 2025
Status verified
Jan 2026
Primary completion
Sep 16, 2028
Completion
Sep 16, 2030

Study Design

Enrollment
120 participants (estimated)

Arms

  • Arm: Young
    Men and women between the ages of 21-35 years will be recruited for this study. All participants will complete an outpatient study day (body composition, blood draw, treadmill test, strength test) and an inpatient study day (muscle biopsies, fat biopsies, indirect calorimetry, exercise test).
  • Arm: Older
    Men and women between the ages of 70-85 years will be recruited for this study. All participants will complete an outpatient study day (body composition, blood draw, treadmill test, strength test) and an inpatient study day (muscle biopsies, fat biopsies, indirect calorimetry, exercise test).

Primary Outcome Measure

Anabolic response [ Time Frame: 2 months ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Mayo ClinicRochesterMinnesota55905
Ian R Lanza, PhD
[email protected]
507-255-8147
Ian R Lanza, PhD (PRINCIPAL_INVESTIGATOR)

Find similar trials in Rochester, MN

By research site
Mayo Clinic· Rochester, MN

Related Studies