Exercise and Monitoring With Post-Hospitalization Muscle Atrophy to Sustain Intrinsic Capacity and Strength

Part of paid clinical trials in Aurora, Colorado.

Sponsor
VA Office of Research and Development
Study ID
NCT06607913
Status
Recruiting
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Conditions

  • Chronic Kidney Disease (CKD)

Eligibility Criteria

Sex
ALL
Age
55 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Exercise — OTHER
    The participants will exercise 2 days a week for 16 weeks. The exercises will include 4 movements: squats, shoulder press, seated row, and bicep curl focusing on internal load and contraction velocity.

Study Details

The aging Veteran population has more frequent inpatient hospitalization than non-Veterans. In addition, older Veterans have an inability to fully recover muscle mass and function after hospital-acquired weakness. The problem of hospital-acquired weakness is greatly increased in at-risk Veteran populations such as those with chronic kidney disease (CKD). The purpose of this collaborative study involving Denver and Baltimore VAMC sites is to improve health through the detection and rehabilitation management of hospital-acquired weakness in those with CKD. The study goals include identifying and monitoring the optimal muscle assessment sites in clinical settings, examining how muscle health impacts length of hospital stay and physical resilience, and determining how home-based and supervised exercise comparatively addresses post-hospitalization physical resilience using performance tests and Veteran feedback.

Key Dates

Start date
Apr 11, 2025
Status verified
Mar 2026
Primary completion
Sep 30, 2028
Completion
Sep 30, 2029

Study Design

Enrollment
250 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: Exercise
    The participants will exercise 2 days a week for 16 weeks. The exercises will include 4 movements: squats, shoulder press, seated row, and bicep curl focusing on internal load and contraction velocity.
  • No Intervention: Usual Care
    Participants will not have any study intervention visits for usual care.

Primary Outcome Measure

Vastus Lateralis Muscle Thickness [ Time Frame: 4 month, 10 month ]

Central Contacts

Locations (2)

FacilityCityStateZIPSite coordinators
Rocky Mountain Regional VA Medical Center, Aurora, COAuroraColorado80045-7211
Katie Boncella, MS
[email protected]
303-724-0687
Michael Harris-Love, DSc MPT BS
[email protected]
(720) 857-2802
Michael Harris-Love, DSc MPT BS (PRINCIPAL_INVESTIGATOR)
Baltimore VA Medical Center VA Maryland Health Care System, Baltimore, MDBaltimoreMaryland21201
Rhianna Patel, MS
[email protected]
410-605-7000
Odessa Addison, PhD
[email protected]
4106057000

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By research site
Rocky Mountain Regional VA Medical Center, Aurora, CO· Aurora, COBaltimore VA Medical Center VA Maryland Health Care System, Baltimore, MD· Baltimore, MD

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