Assessments of Adipogenesis, Lipid Turnover and Cellular Composition in Adipose Tissue in Response to Endurance Exercise

Part of paid clinical trials in Orlando, Florida.

Sponsor
AdventHealth Translational Research Institute
Study ID
NCT06602141
Status
Recruiting
Apply to this trial

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - 45 Years
Healthy Volunteers
Accepted

Interventions

  • Muscle Biopsy — PROCEDURE
    This procedure is used to sample muscle cells from the leg Vastus Lateralis (thigh) muscle.
  • Adipose Biopsy — PROCEDURE
    This procedure is used to sample fat tissue from the abdomen (belly).
  • Glucose Clamp — OTHER
    In this test, we will measure the effect of insulin by giving you insulin and glucose (sugar) intravenously through an IV line in your arm.
  • Accelerometer — OTHER
    The tri-axial accelerometer measure activity and uses those values to estimate the number of calories burned based on your height, weight, age, and gender. The monitor also evaluates physical effort and the body's response to different activities.
  • Endurance Exercise — OTHER
    Visit the study site 3 times a week to engage in endurance exercise training for approximately 12 weeks. Each session will last approximately 75 minutes, and exercise group can choose to use either a stationary bike or a treadmill to complete the training.
  • Physical activity/ dietary habits — OTHER
    Visit the study site bi-weekly to get weight measurements and speak to the study team about weight maintenance and participant physical activity/dietary habits.
  • Heavy Water Labeling Period — OTHER
    Participants in both control groups will be required to drink heavy water, which is ordinary water that is enriched with deuterium (stable, non-radioactive isotope) and called deuterium-labeled water, for 12 weeks.

Study Details

The purpose of this research study is to study the effects of endurance exercise training on adipose (fat) tissue quality and insulin sensitivity in men and women.

Key Dates

Start date
Sep 11, 2024
Status verified
Mar 2026
Primary completion
Apr 30, 2029
Completion
Apr 30, 2029

Study Design

Enrollment
70 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Active Comparator: Control (CTRL) group
  • Active Comparator: Endurance exercise (EX) group

Primary Outcome Measure

In vivo adipogenesis [ Time Frame: Before and following 12 weeks of deuterium (2H) labelled water administration and either endurance exercise training or control (no exercise) ]

Central Contacts

Locations (2)

FacilityCityStateZIPSite coordinators
AdventHealth Translational Research InstituteOrlandoFlorida32804
Recruitment Department
407-303-7100
Lauren Sparks, PhD (PRINCIPAL_INVESTIGATOR)
Pennington Biomedical Research CenterBaton RougeLouisiana70808
Ursula White, PhD
[email protected]
Ursula White, PhD (PRINCIPAL_INVESTIGATOR)

Find similar trials in Orlando, FL

By condition
Obesity / overweight
By specialty
EndocrinologyMetabolic healthWeight loss
By research site
AdventHealth Translational Research Institute· Orlando, FLPennington Biomedical Research Center· Baton Rouge, LA

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