Ixekizumab Concomitantly Administered With Tirzepatide in Adults With Moderate-to-Severe Plaque Psoriasis and Obesity or Overweight

Part of paid clinical trials in Birmingham, Alabama.

Sponsor
Eli Lilly and Company
Study ID
NCT06588283
Phase
PHASE3
Status
Active Not Recruiting

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

Study Details

The main purpose of this study is to demonstrate that when participants with moderate to severe plaque psoriasis and obesity or overweight in the presence of at least 1 weight-related comorbid condition receive ixekizumab and tirzepatide concomitantly administered, participants see improvement in their psoriasis and achieve weight reduction compared to when receiving ixekizumab. Participation in this study includes up to 12 visits and could last up to 61 weeks including screening, open label treatment period, and post-treatment follow-up period.

Key Dates

Start date
Sep 30, 2024
Status verified
Jan 2026
Primary completion
Jan 8, 2026
Completion
May 31, 2026

Study Design

Enrollment
250 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: Ixekizumab
    Ixekizumab administered subcutaneous (SC).
  • Experimental: Ixekizumab and Tirzepatide
    Ixekizumab concomitantly administered with tirzepatide SC.

Primary Outcome Measure

Percentage of Participants Who Simultaneously Achieved Psoriasis Area and Severity Index (PASI) 100 and At Least 10% Weight Reduction [ Time Frame: Baseline to Week 36 ]

Locations (68)

FacilityCityStateZIPSite coordinators
Total Skin & Beauty Dermatology Center, PC DBA Total DermatologyBirminghamAlabama35203-
Medical Dermatology SpecialistsPhoenixArizona85006-
Scottsdale Clinical TrialsScottsdaleArizona85260-
Yuma Clinical TrialsYumaArizona85365-
Johnson DermatologyFort SmithArkansas72916-
California Dermatology & Clinical Research InstituteEncinitasCalifornia92024-
First OC Dermatology Research IncFountain ValleyCalifornia92708-
Avance Clinical TrialsLaguna NiguelCalifornia92677-
Dermatology Research AssociatesLos AngelesCalifornia90045-
Metropolis DermatologyLos AngelesCalifornia90017-
Northridge Clinical TrialsNorthridgeCalifornia91325-
Cura Clinical Research - OxnardOxnardCalifornia93030-
Integrative Skin Science and Research - Location 2SacramentoCalifornia95815-
Therapeutics Clinical ResearchSan DiegoCalifornia92123-
Life Clinical TrialsCoral SpringsFlorida33071-
Alliance for Multispecialty Research, LLCFort MyersFlorida33912-
NeoClinical ResearchHialeahFlorida33016-
Encore Medical ResearchHollywoodFlorida33024-
Skin Care ResearchHollywoodFlorida33021-
Solutions Through Advanced ResearchJacksonvilleFlorida32256-
Deluxe Health CenterMiami LakesFlorida33014-
Renstar Medical ResearchOcalaFlorida34470-
Leading Edge DermatologyPlantationFlorida33317-
International Clinical Research - SanfordSanfordFlorida32771-
Nodal Medical CenterTampaFlorida33607-
Palm Harbor Dermatology PA d/b/a TrueBlue Clinical ResearchTampaFlorida33609-
DeNova ResearchChicagoIllinois60602-
Oak DermatologyNapervilleIllinois60563-
Dawes Fretzin Clinical Research Group, LLCIndianapolisIndiana46250-
The Indiana Clinical Trials Center, PCPlainfieldIndiana46168-
Equity Medical - Bowling GreenBowling GreenKentucky42104-
DelRicht ResearchBaton RougeLouisiana70809-
Care Access - Lake Charles (Bayou Pines)Lake CharlesLouisiana70601-
Dermatology and Skin Cancer Specialists, LLCRockvilleMaryland20850-
Lawrence J. Green, MD, LLCRockvilleMaryland20850-
Great Lakes Research Group, Inc.Bay CityMichigan48706-
The Derm Institute of West MichiganCaledoniaMichigan49316-
MI Skin InnovationsNorthvilleMichigan48167-
Las Vegas DermatologyLas VegasNevada89144-
Skin Cancer and Dermatology Institute - RenoRenoNevada89509-
ActivMed Practices & Research, LLC.PortsmouthNew Hampshire03801-
Psoriasis Treatment Center of Central New JerseyEast WindsorNew Jersey08520-
Care Access - HobokenHobokenNew Jersey07030-
Equity MedicalNew YorkNew York10023-
Mount Sinai Doctors - East 85th StreetNew YorkNew York10028-
Onsite Clinical Solutions - HuntersvilleHuntersvilleNorth Carolina28078-
Red River Research PartnersFargoNorth Dakota58103-
Optima Research - BoardmanBoardmanOhio44512-
Dermatologists of Southwest OhioMasonOhio45040-
Oregon Dermatology and Research CenterPortlandOregon97210-
Oregon Medical Research CenterPortlandOregon97201-
Dermatology Associates of Plymouth MeetingPlymouth MeetingPennsylvania19462-
Columbia Dermatology & AestheticsColumbiaSouth Carolina29212-
International Clinical Research - Tennessee LLCMurfreesboroTennessee37130-
DelRicht Research - Thompson's StationSmyrnaTennessee37167-
Tekton Research - Westlake DriveAustinTexas78746-
Bellaire Dermatology AssociatesBellaireTexas77401-
Modern Research Associates, PLLCDallasTexas75231-
Austin Institute for Clinical ResearchPflugervilleTexas78660-
Dermatology Clinical Research Center of San AntonioSan AntonioTexas78229-
Progressive Clinical ResearchSan AntonioTexas78213-
Texas Dermatology and Laser SpecialistsSan AntonioTexas78218-
Tanner ClinicLaytonUtah84041-
Care Access - ArlingtonArlingtonVirginia22206-
Care Access - DanvilleDanvilleVirginia24541-
Virginia Clinical Research, Inc.NorfolkVirginia23502-
Bellevue Dermatology ClinicBellevueWashington98004-
Dermatology of SeattleBurienWashington98168-

Related coverage on Hipa.ai

Find similar trials in Birmingham, AL

By condition
Obesity / overweightPsoriasis
By specialty
EndocrinologyMetabolic healthWeight lossDermatologyRheumatologyAutoimmune disease
By research site
Total Skin & Beauty Dermatology Center, PC DBA Total Dermatology· Birmingham, ALMedical Dermatology Specialists· Phoenix, AZScottsdale Clinical Trials· Scottsdale, AZYuma Clinical Trials· Yuma, AZJohnson Dermatology· Fort Smith, ARCalifornia Dermatology & Clinical Research Institute· Encinitas, CA

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