Effect of Small Interfering RNA Inclisiran on Carotid Plaques As Assessed by Carotid Ultrasound

Sponsor
First Affiliated Hospital of Xinjiang Medical University
Study ID
NCT06586684
Phase
PHASE4
Status
Not Yet Recruiting

Notify me when recruiting opens

Save your spot on the interest list for this study. We'll keep your details with this study so our team can follow up when recruiting opens.

Not yet recruiting

Add your contact details and location so we can keep your interest tied to this study.

Conditions

  • Carotid Plaque
  • Echocardiography
  • Hyperlipidemia

Eligibility Criteria

Sex
ALL
Age
18 Years - 75 Years
Healthy Volunteers
Not accepted

Interventions

  • Inclisiran — DRUG
    Patients with carotid plaques undergoing treatment with inclisiran

Study Details

Current understanding suggests that the majority of cardiovascular events are driven by vulnerable plaques. Nonetheless, the impact of PCSK9 inhibitors on the stability of carotid plaques remains insufficiently elucidated, with a notable scarcity of relevant clinical studies. This investigation seeks to address this gap through a real-world study conducted among patients with arterial sclerosis in Asia. The primary aim is to evaluate the effects of small interfering RNA (inclisiran) on carotid plaque characteristics as assessed by ultrasound, thereby contributing valuable data to inform clinical practice.

Key Dates

Start date
Sep 20, 2024
Status verified
Sep 2024
Primary completion
Sep 30, 2025
Completion
Sep 30, 2026

Study Design

Enrollment
40 participants (estimated)
Allocation
NON_RANDOMIZED
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT

Arms

  • Experimental: inclisiran Therapy group
    Patients with carotid plaques undergoing treatment with inclisiran

Primary Outcome Measure

CIMT [ Time Frame: Immediately and treated with inclisiran one year later ]

Central Contacts

Related Studies