CT Evaluation of Carotid Plaque Components

Conditions

• Carotid Plaque

Eligibility Criteria

Sex

ALL

Age

18 Years - N/A

Healthy Volunteers

Not accepted

Study Details

The goal of this observational study is to validate the diagnostic performance of photon counting/spectral CT to distinguish tissue components in ischemic stroke with MRI, semi-automated segmentation software or histology as the reference standard. The main question\[s\] it aims to answer are: 1. Presence or absence of calcium, hemorrhage, and lipid plaque components as determined on CT will be confirmed with carotid MRI, segmentation quantitative (e.g., volume) output from segmentation software, or histologic staining. 2. Volumes of hemorrhage, lipid, and calcium components will be measured to determine plaque phenotype and correlated with ipsilateral intracranial stroke burden. Participants will be asked to do the following: Aim 1: * 1 Photon counting/spectral CT angiography of the neck * 1 Research Carotid/Neck MRI of the carotid arteries (if eligible) Aim 2: * 1 Research Carotid/Neck MRI of the carotid arteries (if eligible) * 1 Photon counting/spectral CT angiography of the neck * 1 Carotid plaque tissue from participants surgery will be retrieved, imaged, and stained (if eligible)

Key Dates

Start date

Oct 1, 2023

Status verified

Nov 2025

Primary completion

Aug 31, 2026

Completion

Dec 31, 2028

Study Design

Enrollment

70 participants (estimated)

Primary Outcome Measure

To validate the diagnostic performance of photon counting/spectral CT [ Time Frame: 3years ]

Central Contacts

• Marisa Sanchez
  215-901-9994
  [email protected]
• Leeanne Lezotte
  856-364-3137
  [email protected]

Locations (1)

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