Lynch Syndrome Integrative Epidemiology and Genetics

Part of paid clinical trials in Aurora, Colorado.

Sponsor
University of Colorado, Denver
Study ID
NCT06582914
Status
Recruiting
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Conditions

  • Lynch Syndrome

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Study Details

The vision of the "Lynch syndrome INtegrative Epidemiology And GEnetics" (LINEAGE) Consortium is to collaboratively improve the lives and longevity of individuals and families with Lynch syndrome. The mission of the LINEAGE Consortium is to collaboratively improve Lynch syndrome care through high-quality research. This consortium will provide intellectual and infrastructure support to facilitate development of research questions, collection of standardized data and biospecimens, support of grant applications, and generation of collaborative manuscripts. Our aims are to: I. Establish a prospective cohort of individuals with Lynch syndrome II. Collect standardized longitudinal clinical and biosample data to elucidate Lynch Syndrome epidemiology and gene-host interactions III. Promote intervention trials to improve cancer prevention and early detection in Lynch Syndrome

Key Dates

Start date
Oct 1, 2024
Status verified
Jan 2025
Primary completion
Dec 31, 2054
Completion
Dec 31, 2054

Study Design

Enrollment
5,000 participants (estimated)

Arms

  • Arm: Pateints with a germline variant in a mismatch repair gene
    Individuals with germline genetic testing results showing a pathogenic, likely pathogenic or variant of uncertain significance in MLH1, MSH2, MSH6, PMS2 or EPCAM.

Primary Outcome Measure

Colorectal cancer incidence [ Time Frame: 40 years ]

Central Contacts

Locations (2)

FacilityCityStateZIPSite coordinators
University of ColoradoAuroraColorado80045
Sandra Boimbo, MPH
[email protected]
303-724-8892
Swati G Patel, MD, MS
University of ChicagoChicagoIllinois60637
Ophir Gilad
[email protected]
774-702-1000
Sonia Kupfer, MD

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