Aging, Beta Blockers, and Thermoregulatory Responses

Part of paid clinical trials in Dallas, Texas.

Sponsor
University of Texas Southwestern Medical Center
Study ID
NCT06582680
Phase
PHASE4
Status
Recruiting
Apply to this trial

Conditions

  • Aging
  • Heat Stress

Eligibility Criteria

Sex
ALL
Age
65 Years - N/A
Healthy Volunteers
Accepted

Interventions

  • Ambient Heat — OTHER
    Subjects will spend 3-hours in a heat chamber at 41°C and 40% humidity.

Study Details

This study will test the hypothesis that the drugs propranolol and metoprolol will result in greater increases in core body temperature during 3 hours of extreme heat exposure in older adults.

Key Dates

Start date
Oct 4, 2024
Status verified
Oct 2025
Primary completion
Sep 30, 2026
Completion
Sep 30, 2026

Study Design

Enrollment
22 participants (estimated)
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: Placebo, then Propranolol, then Metoprolol
  • Experimental: Placebo, then Metoprolol, then Propranolol
  • Experimental: Propranolol, then Placebo, then Metoprolol
  • Experimental: Propranolol, then Metoprolol, then Placebo
  • Experimental: Metoprolol, then Placebo, then Propranolol
  • Experimental: Metoprolol, then Propranolol, then Placebo

Primary Outcome Measure

Internal temperature [ Time Frame: Continuously throughout the 3-hour heat exposure. ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
IEEM Texas Health Presbyterian Hospital DallasDallasTexas75231
Taysom Wallace, MS
[email protected]
214-345-5022
Courtney Kirby, RN
[email protected]
214-345-6502
Craig Crandall, PhD (PRINCIPAL_INVESTIGATOR)

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By research site
IEEM Texas Health Presbyterian Hospital Dallas· Dallas, TX

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