Avoidance-driven Decision Making and Learning in Anorexia Nervosa and Bulimia Nervosa

Part of paid clinical trials in La Jolla, California.

Sponsor
University of California, San Diego
Study ID
NCT06566612
Status
Recruiting
Apply to this trial

Conditions

  • Anorexia Nervosa
  • Bulimia Nervosa

Eligibility Criteria

Sex
FEMALE
Age
18 Years - 39 Years
Healthy Volunteers
Accepted

Study Details

The purpose of this study is to investigate areas of the brain responsible for avoidance learning in adults with eating disorders using brain imaging techniques, computer tasks, and self-report questionnaires and interviews. The investigators will study changes in brain activity using a procedure called functional magnetic resonance imaging (fMRI). This study will include 78 women with an eating disorder (26 with anorexia nervosa \[AN\], 26 with bulimia nervosa \[BN\]) and 26 healthy controls (HC) aged 18-39. Aim 1: Evaluate behavioral differences in active and passive avoidance learning in eating disorders and associations with symptoms. Aim 2: Evaluate whether corticostriatal and limbic-prefrontal fMRI BOLD response associated with avoidance learning differs in eating disorders relative to healthy controls and relates to symptoms. Aim 3: Evaluate whether functional connectivity of avoidance learning neural circuity differs in eating disorders relative to healthy controls.

Key Dates

Start date
Aug 1, 2024
Status verified
Apr 2026
Primary completion
Jul 31, 2026
Completion
Jul 31, 2027

Study Design

Enrollment
78 participants (estimated)

Arms

  • Arm: Anorexia Nervosa
    Participants that meet Diagnostic And Statistical Manual Of Mental Disorders (DSM-V) criteria for Anorexia Nervosa.
  • Arm: Bulimia Nervosa
    Participants that meet DSM-V criteria for Bulimia Nervosa.
  • Arm: Healthy Controls
    Participants that do not meet DSM-V criteria for any disorder.

Primary Outcome Measure

Learning rate [ Time Frame: 25 minutes ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
UCSD Eating Disorders Treatment and Research ProgramLa JollaCalifornia92121
Sophie R Abber, MS
[email protected]
858-534-0371
Katherine Gandee, BS
[email protected]
858-534-0371
Christina E Wierenga, PhD (PRINCIPAL_INVESTIGATOR)

Find similar trials in La Jolla, CA

By research site
UCSD Eating Disorders Treatment and Research Program· La Jolla, CA

Related Studies