Incentive Processing and Learning in Anorexia Nervosa and Bulimia Nervosa

Part of paid clinical trials in La Jolla, California.

Sponsor
University of California, San Diego
Study ID
NCT05056597
Status
Recruiting
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Conditions

  • Anorexia Nervosa
  • Bulimia Nervosa

Eligibility Criteria

Sex
FEMALE
Age
18 Years - 39 Years
Healthy Volunteers
Accepted

Study Details

The purpose of this study is to investigate areas of the brain responsible for 'liking', 'wanting', and learning in adults with eating disorders using brain imaging techniques, computer tasks, a test meal, and self-report questionnaires and interviews. The investigators will study changes in brain activity using a procedure called functional magnetic resonance imaging (fMRI). This study will include 252 women with an eating disorder (63 AN-restricting type (AN-R), 63 AN-binge eating/purging type (AN-BP), 63 bulimia nervosa (BN)) and 63 healthy controls (HC) aged 18-39. Aim 1: To examine neural differences in 'liking' and 'wanting' in ED relative to HC. Aim 2: To examine differences in instrumental learning for reward and punishment in ED relative to HC. Aim 3: To examine how 'liking' and 'wanting' drive instrumental learning in ED and predict clinical symptoms at baseline and 1 year later. Exploratory Aim: To explore the associations of dopamine function, as measured by neuromelanin MRI (NM-MRI), with ED diagnosis and brain response to 'liking', 'wanting', and learning.

Key Dates

Start date
May 26, 2022
Status verified
Apr 2026
Primary completion
Jan 31, 2027
Completion
Jan 31, 2027

Study Design

Enrollment
252 participants (estimated)

Arms

  • Arm: AN-R
    Participants that meet Diagnostic And Statistical Manual Of Mental Disorders (DSM-V) criteria for Anorexia Nervosa restricting subtype.
  • Arm: AN-BP
    Participants that meet DSM-V criteria for Anorexia Nervosa binging/purging subtype
  • Arm: BN
    Participants that meet DSM-V criteria for Bulimia Nervosa.
  • Arm: Healthy Controls
    Participants that do not meet DSM-V criteria for any disorder.

Primary Outcome Measure

BOLD response [ Time Frame: 1 Year ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
UCSD Eating Disorders Treatment and Research ProgramLa JollaCalifornia92121
Megan Martinho
[email protected]
858-210-0318
Katherine Gandee
[email protected]
858-534-0371
Christina Wierenga (PRINCIPAL_INVESTIGATOR)

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UCSD Eating Disorders Treatment and Research Program· La Jolla, CA

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