Variability in Analgesic Response to Ibuprofen

Part of paid clinical trials in Philadelphia, Pennsylvania.

Sponsor
University of Pennsylvania
Study ID
NCT06539741
Status
Recruiting
Apply to this trial

Conditions

  • Impacted Third Molar Tooth
  • Pain, Acute

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Accepted

Study Details

Nonsteroidal anti-inflammatory drugs (NSAIDs), like ibuprofen, are recommended as first-line treatment for post-surgical dental pain. However, there is variability in analgesic response, and some patients require supplemental opioids for adequate pain relief. The goal of this study is to identify the factors that contribute to the need for opioid after third molar extraction to help limit unnecessary opioid prescriptions in patients who will have good pain relief with ibuprofen alone.

Key Dates

Start date
Jan 3, 2025
Status verified
May 2026
Primary completion
Sep 30, 2027
Completion
Sep 30, 2027

Study Design

Enrollment
200 participants (estimated)

Arms

  • Arm: Complete Responders
    Patients who do not require supplemental opioids, in addition to a standard-of-care NSAID-based pain management regimen, for pain relief following third molar extraction
  • Arm: Partial Responders
    Patients who require supplemental opioids (oxycodone 5 mg), in addition to a standard-of-care NSAID-based pain management regimen, for pain relief following third molar extraction

Primary Outcome Measure

Supplemental Opioid Use [ Time Frame: Up to 7 days after third molar extraction ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
University of Pennsylvania School of Dental MedicinePhiladelphiaPennsylvania19104
Stacey Secreto
[email protected]
215-746-8871
Katherine N Theken, PharmD, PhD (PRINCIPAL_INVESTIGATOR)
Elliot V Hersh, DMD, MS, PhD (SUB_INVESTIGATOR)
Neeraj Panchal, DDS, MA, MD (SUB_INVESTIGATOR)

Find similar trials in Philadelphia, PA

By research site
University of Pennsylvania School of Dental Medicine· Philadelphia, PA

Related Studies