Prediction Augmented Screening Initiative

Conditions

• Lung Cancer
• Lung Cancer Screening

Eligibility Criteria

Sex

ALL

Age

50 Years - 80 Years

Healthy Volunteers

Not accepted

Interventions

• PCP-Facing Tools — OTHER
  PCP-facing tools will be turned on as a package: a) enhanced LCS clinical reminder including DP+ generated smart message; b) Integrated one-click DP+ full decision tool for automating personalized information about the net benefit of LCS based on patient characteristics; c) the TurboHM tool: automated Health maintenance app for tracking all preventive care, including a dedicated LCS section with personalized information
• LCS team population management tools — OTHER
  site-specific dashboard and proactive outreach toolkit

Study Details

Lung cancer is responsible for more deaths in the United States than breast, prostate and colon cancer combined and is the number one cancer killer of Veterans. This is because lung cancer is usually diagnosed when the disease has spread, and cure is less likely. Lung cancer screening (LCS) finds cancer at an earlier stage when it is curable, yet only 20% of eligible Veterans have been screened. Uptake is even lower among Black Veterans despite higher lung cancer risk. Using prediction models to identify high-benefit people for whom LCS should be encouraged improves efficiency and reduces disparities. Moreover, it is more patient-centered as shared decision-making conversations can be tailored with personalized information. The US Preventive Services Task Force has called for research to demonstrate that prediction-augmented LCS can be feasibly implemented at the point-of-care. The investigators propose for VA to lead this effort with a large-scale pragmatic clinical trial to show that prediction-augmented LCS is both feasible and improves LCS uptake.

Key Dates

Start date

Jun 1, 2026

Status verified

Apr 2026

Primary completion

Mar 5, 2029

Completion

Sep 30, 2029

Study Design

Enrollment

23,520 participants (estimated)

Allocation

RANDOMIZED

Intervention model

FACTORIAL

Primary purpose

SCREENING

Arms

• No Intervention: Usual Care
  Usual care
• Experimental: PCP facing tools
  Suite of PCP facing tools activated
• Experimental: LCS team population management tools
  site-specific dashboard and proactive outreach toolkit
• Experimental: PCP facing tools plus LCS population management dashboard
  both interventions activated

Primary Outcome Measure

LDCT receipt in high-benefit Veterans [ Time Frame: From time of intervention activation at the facility to the receipt of LDCT scan up to 169 weeks ]

Central Contacts

• Nichole T Tanner, MD MS BS
  (843) 789-7341
  [email protected]
• Abby G Wenzel, PhD MS BS
  (843) 789-6965
  [email protected]

Locations (4)

Find similar trials in Bedford, MA

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