Correlation Between Noninvasive Blood Vessel Functionality Parameters and Cerebral Hemodynamics in Neurocritical Care Patients

Part of paid clinical trials in Louisville, Kentucky.

Sponsor
University of Louisville
Study ID
NCT06511804
Status
Recruiting
Apply to this trial

Conditions

  • Brain Injuries
  • Intracranial Pressure Increase
  • Monitoring

Eligibility Criteria

Sex
ALL
Age
18 Years - 100 Years
Healthy Volunteers
Not accepted

Interventions

  • Intracranial Pressure Noninvasive Monitoring — DEVICE
    Mespere sensors will be placed on the temporal areas of the head in patients with invasive intracranial pressure monitoring. Blood pressures, intracranial pressure, and Mespere parameters will be recorded.

Study Details

The purpose of this clinical research project is to employ Mespere LifeSciences NeurOs Cerebral Oximetry system, equipped with noninvasive sensors approved by the FDA, to monitor and investigate the correlation within a cohort of patients suffering from traumatic brain injury (TBI), stroke, brain tumor, and brain bleeding. This study aims to investigate and establish the correlation between blood vessel functionality parameters-specifically, Vasodilation/Constriction Index (VDC), Vascular Resistance Index (VR), and Volume Reactivity Index (VRx)-with the crucial physiological indicators, Intracranial Pressure (ICP) and Mean Arterial Pressure (MAP). By doing so, the investigators seek to address fundamental questions surrounding cerebral hemodynamics and autoregulation in various neurological conditions.

Key Dates

Start date
Nov 17, 2024
Status verified
May 2025
Primary completion
Dec 30, 2025
Completion
Jun 30, 2026

Study Design

Enrollment
25 participants (estimated)

Primary Outcome Measure

cerebral hemodynamics and autoregulation as assessed by the noninvasive blood vessel functionality parameters-Vasodilation/Constriction Index (VDC), Vascular Resistance Index (VR), and Volume Reactivity Index (VRx) [ Time Frame: 1 hour ]

Locations (1)

FacilityCityStateZIPSite coordinators
University of Louisville HealthLouisvilleKentucky40202
Jiapeng Huang, MD, PhD
[email protected]
5028528157
Jiapeng Huang, Md, PhD (PRINCIPAL_INVESTIGATOR)

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By research site
University of Louisville Health· Louisville, KY

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