Differential Thrombogenesis by EPA and DHA Mediated by HDL

Part of paid clinical trials in Providence, Rhode Island.

Sponsor
The Miriam Hospital
Study ID
NCT06494488
Phase
EARLY_PHASE1
Status
Recruiting
Apply to this trial

Conditions

  • Hypertriglyceridemia
  • Lipid Metabolism Disorders

Eligibility Criteria

Sex
ALL
Age
18 Years - 69 Years
Healthy Volunteers
Not accepted

Interventions

  • EPA — DRUG
    Fish oil
  • DHA — DRUG
    Fish oil

Study Details

The goal of this study is to learn more about omega-3 polyunsaturated fatty acids supplementation on blood lipid profile and platelets in patients with high cholesterol levels. The purpose of this research is to gather information on the safety and effect of two different fish oils, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). Participants will: Visit the clinic 3 times during study checkups, tests and blood collection. Randomized to either the EPA or the DHA supplementation group. Be given a 28-day food and activity log.

Key Dates

Start date
Jul 10, 2025
Status verified
Sep 2025
Primary completion
Aug 1, 2027
Completion
Mar 31, 2028

Study Design

Enrollment
80 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SCREENING

Arms

  • Experimental: DHA group
    Participants will receive DHA supplement. 3 gelcaps, three times per day with meals (breakfast, lunch, and dinner). DHA supplement regimen contains 450 mg DHA and minimal EPA (60 mg) per pill. Participants will be given 28-day food and activity log.
  • Experimental: EPA group
    Participants will receive EPA supplement. 2 gelcaps, two times per day with meals (breakfast and dinner). 1 gelcap consists of 1 gram of EPA. Participants will be given 28-day food and activity log.

Primary Outcome Measure

Percentage of Platelet Aggregation Area Under the Curve (AUC) Over Time [ Time Frame: 8 weeks ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Brown University Health - Lipid ClinicProvidenceRhode Island02914
Wenliang Song, MD
[email protected]
267 951 77 59

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By research site
Brown University Health - Lipid Clinic· Providence, RI

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