Speech Motor Learning and Retention (Aim 2)

Part of paid clinical trials in New Haven, Connecticut.

Sponsor
Yale University
Study ID
NCT06491823
Status
Recruiting
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Conditions

  • Speech

Eligibility Criteria

Sex
ALL
Age
18 Years - 40 Years
Healthy Volunteers
Accepted

Interventions

  • Adaptation — BEHAVIORAL
    Auditory adaptation in speech
  • Adaptation baseline — BEHAVIORAL
    Auditory baseline in speech
  • Motor evoked potentials — DEVICE
    motor evoked potentials will be obtained in each recording block
  • Auditory evoked potentials — DEVICE
    auditory evoked potentials will be obtained in each recording block
  • Somatosensory evoked potentials — DEVICE
    Somatosensry evoked potentials will be obtained in each recording block

Study Details

The overall goal of this research is to test a new model of speech motor learning, whose central hypothesis is that learning and retention are associated with plasticity not only in motor areas of the brain but in auditory and somatosensory regions as well. The strategy for the proposed research is to identify individual brain areas that contribute causally to retention by disrupting their activity with transcranial magnetic stimulation (TMS). Investigators will also use functional magnetic resonance imaging (fMRI) which will enable identification of circuit-level activity which predicts either learning or retention of new movements, and hence test the specific contributions of candidate sensory and motor zones. In other studies, investigators will record sensory and motor evoked potentials over the course of learning to determine the temporal order in which individual sensory and cortical motor regions contribute. The goal here is to identify brain areas in which learning-related plasticity occurs first and which among these areas predict subsequent learning.

Key Dates

Start date
Oct 1, 2024
Status verified
Feb 2026
Primary completion
Nov 30, 2028
Completion
May 31, 2029

Study Design

Enrollment
120 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: MEPs (M1) / altered auditory feedback / MEPs + retention tests at 24h
    Evoked potentials will be recorded from brain area M1 (motor cortex) in combination with a speech motor learning procedure known as adaptation to altered auditory feedback. Retention of learning will be tested 24h later along with additional evoked potential recordings.
  • Experimental: AEPs (A1) / altered auditory feedback / AEPs + retention tests at 24h
    Evoked potentials will be recorded from brain area A1 (auditory cortex) in combination with a speech motor learning procedure known as adaptation to altered auditory feedback. Retention of learning will be tested 24h later along with additional evoked potential recordings.
  • Experimental: SEPs (S1) / altered auditory feedback / SEPs + retention tests at 24h
    Evoked potentials will be recorded from brain area S1 (somatosensory cortex) in combination with a speech motor learning procedure known as adaptation to altered auditory feedback. Retention of learning will be tested 24h later along with additional evoked potential recordings.
  • Experimental: MEPs (M1) / unaltered auditory feedback / MEPs + retention tests at 24h
    Evoked potentials will be recorded from brain area M1 (motor cortex) in combination with unaltered auditory feedback. Retention of learning will be tested 24h later along with additional evoked potential recordings.
  • Experimental: AEPs (A1) / unaltered auditory feedback / AEPs + retention tests at 24h
    Evoked potentials will be recorded from brain area A1 (auditory cortex) in combination with unaltered auditory feedback. Retention of learning will be tested 24h later along with additional evoked potential recordings.
  • Experimental: SEPs (S1) / unaltered auditory feedback / SEPs + retention tests at 24h
    Evoked potentials will be recorded from brain area S1 (somatosensory cortex) in combination with unaltered auditory feedback. Retention of learning will be tested 24h later along with additional evoked potential recordings.

Primary Outcome Measure

Speech motor learning [ Time Frame: Performance as measured at the end of learning (30 minute session) ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Yale Child Study CenterNew HavenConnecticut06520-

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Yale Child Study Center· New Haven, CT

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