Speech Motor Learning and Retention (Master Protocol)

Part of paid clinical trials in New Haven, Connecticut.

Sponsor
Yale University
Study ID
NCT06467292
Status
Recruiting
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Conditions

  • Speech

Eligibility Criteria

Sex
ALL
Age
18 Years - 40 Years
Healthy Volunteers
Accepted

Interventions

  • continuous theta-burst stimulation (cTBS) — DEVICE
    cTBS stimulation will be applied to different areas of the brain following learning. Stimulation will take place following learning in order to block motor memory retention.
  • Adaptation — BEHAVIORAL
    Auditory adaptation in speech
  • Single pulse Transcranial magnetic stimulation (TMS) — DEVICE
    TMS will be delivered 10 times in each motor evoked potentials (MEP) recording block.
  • fMRI — DEVICE
    To assess functional connectivity patterns between regions that predict learning.

Study Details

The overall goal of this research is to test a new model of speech motor learning, whose central hypothesis is that learning and retention are associated with plasticity not only in motor areas of the brain but in auditory and somatosensory regions as well.

Key Dates

Start date
Oct 1, 2024
Status verified
Feb 2026
Primary completion
Nov 30, 2028
Completion
May 31, 2029

Study Design

Enrollment
330 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: Speech Motor Learning and Retention Aim 1
    Aim 1: Participants will perform learning tasks while receiving altered/unaltered auditory feedback with cTBS applied to the appropriate area of the brain following learning. Retention of learning is assessed 24 hours later.
  • Experimental: Speech Motor Learning and Retention Aim 2
    Aim 2: Participants will perform learning tasks combined with shifted auditory feedback. Motor cortical excitability will be measured using single-pulse TMS to elicit motor evoked potentials.
  • Experimental: Speech Motor Learning and Retention Aim 3
    Aim 3: Participants will have fMRI with behavioral measures of speech motor learning.

Primary Outcome Measure

Speech motor learning [ Time Frame: Performance as measured at the end of learning (30 minute session) ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Yale Child Study CenterNew HavenConnecticut06520-

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Yale Child Study Center· New Haven, CT

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