Modeling Host-Pathogen Interaction Using Lymphoid Organoids
Part of paid clinical trials in Bethesda, Maryland.
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
- Study ID
- NCT06479837
- Status
- Recruiting
Conditions
- Staphylococcal Infections
Eligibility Criteria
- Sex
- ALL
- Age
- 2 Years - 120 Years
- Healthy Volunteers
- Not accepted
Study Details
Background: Staphylococcus aureus (S.aureus) are bacteria that can make people sick. Sometimes, an S. aureus infection can develop inside the spine; these infections can lead to paralysis and death. Researchers do not know how S. aureus interacts with a person s cells to cause infections in the spine. Objective: To learn how S. aureus interacts with cells in the body using tissues from tonsils discarded after standard surgery to remove them. Eligibility: People aged 2 years and older who are scheduled to have their tonsils removed. Design: Researchers will select participants for the study based on review of their existing medical records, including results of blood tests; any imaging scans, including x-rays; and reports about tissue specimens. Participants will answer questionnaires about their health and past infections. They can do this online or on paper. Participants will collect a nasal swab 1 week before their surgery. They will be given a tool that looks like a long cotton swab. They will twirl it around inside their nose. The swab will pick up cells and fluids that will be used for research. After their surgery, the participant s surgeon will save samples of tonsil tissue. The surgeon will send these tissue samples and the nasal swab to researchers at the NIH. These tissues and the swab will be used in studies to help researchers understand how S. aureus interacts with cells in the body. They hope these studies will help them find better ways to treat S. aureus infections.
Key Dates
- Start date
- Jun 16, 2026
- Status verified
- Dec 2025
- Primary completion
- Dec 1, 2043
- Completion
- Dec 1, 2044
Study Design
- Enrollment
- 500 participants (estimated)
Arms
- Arm: Tonsillectomy PatientsPatients undergoing tonsillectomy as part of their clinical care
Primary Outcome Measure
Immune cell composition [ Time Frame: At time of collection ]
Central Contacts
- Katherine Le, M.D.(301) 761-7166
- Michael Otto, M.D.(406) 363-9394
Locations (2)
| Facility | City | State | ZIP | Site coordinators |
|---|---|---|---|---|
| National Institute of Allergy and Infectious Diseases (NIAID) | Bethesda | Maryland | 20892 | - |
| National Institutes of Health Clinical Center | Bethesda | Maryland | 20892 |