Multimodal Investigation of Neural Plasticity

Part of paid clinical trials in Ann Arbor, Michigan.

Sponsor
University of Michigan
Study ID
NCT06453980
Status
Recruiting
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Conditions

  • Mild Cognitive Impairment

Eligibility Criteria

Sex
ALL
Age
60 Years - N/A
Healthy Volunteers
Accepted

Interventions

  • sham tDCS — DEVICE
    Participants will receive sham (placebo) HD-tDCS for 20 minutes, for 1 session.
  • active tDCS — DEVICE
    Participants will receive HD-tDCS at 3 milliAmp for 20 minutes, for 1 session.

Study Details

This study will evaluate the effects of a form of non-invasive brain stimulation on brain functioning and memory in cognitively intact older adults (healthy controls, HC) and in those with mild cognitive impairment (MCI).

Key Dates

Start date
May 13, 2024
Status verified
Mar 2026
Primary completion
Apr 30, 2026
Completion
Apr 30, 2026

Study Design

Enrollment
80 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Sham Comparator: HC sham tDCS
    Sham (placebo) dose of HD-tDCS treatment for 20 minutes, for 1 session.
  • Experimental: HC active tDCS
    3 milliAmp dose of HD-tDCS treatment for 20 minutes, for 1 session.
  • Sham Comparator: MCI sham tDCS
    Sham (placebo) dose of HD-tDCS treatment for 20 minutes, for 1 session.
  • Experimental: MCI active tDCS
    3 milliAmp dose of HD-tDCS treatment for 20 minutes, for 1 session.

Primary Outcome Measure

Changes in glutamate concentration (fMRS) [ Time Frame: average on 1 week ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
University of MichiganAnn ArborMichigan48109
Alexandru Iordan, Ph.D
[email protected]
734-764-2909
Alexandru Iordan, Ph.D (PRINCIPAL_INVESTIGATOR)

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University of Michigan· Ann Arbor, MI

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