Effects of THC on Alcohol Consumption and Neural Correlates of Reward

Part of paid clinical trials in Aurora, Colorado.

Sponsor
University of Colorado, Denver
Study ID
NCT06446479
Phase
PHASE2
Status
Recruiting
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Conditions

  • Cannabis Use Disorder

Eligibility Criteria

Sex
ALL
Age
21 Years - 40 Years
Healthy Volunteers
Accepted

Interventions

  • Dronabinol Pill — DRUG
    Dronabinol 20 mg
  • Placebo — DRUG
    placebo

Study Details

Alcohol and cannabis are often used together such that their effects overlap, but little is known about the neural mechanisms that underlie simultaneous use. High doses of THC have not been well-studied in the laboratory, and it is unclear how high doses of THC may impact alcohol consumption patterns. The proposed study will explore the effects of oral THC (20mg dronabinol) vs. placebo on neural reward, alcohol self-administration and naturalistic co-use patterns.

Key Dates

Start date
Jul 1, 2024
Status verified
Aug 2024
Primary completion
Jun 30, 2026
Completion
Jun 30, 2026

Study Design

Enrollment
28 participants (estimated)
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: Placebo first, Dronabinol second
    This arm will receive placebo on the first visit, and dronabinol on the second visit
  • Experimental: Dronabinol first, Placebo second
    This arm will receive dronabinol on the first visit, and placebo on the second visit.

Primary Outcome Measure

Change in alcohol cue-elicited brain activation (fMRI) between medication periods [ Time Frame: 1 hour after administration of a single dose of study medication at 7 days, 14 days. ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
University of Colorado Anschutz Medical CampusAuroraColorado80045
Elnaz Nourollahimoghadam, MD
[email protected]
303-724-6020

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By research site
University of Colorado Anschutz Medical Campus· Aurora, CO

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