Adversity, Brain and Opioid Use Study

Part of paid clinical trials in Ann Arbor, Michigan.

Sponsor
University of Michigan
Study ID
NCT06355778
Status
Recruiting
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Conditions

  • Healthy
  • Opioid Use Disorder

Eligibility Criteria

Sex
ALL
Age
18 Years - 55 Years
Healthy Volunteers
Accepted

Interventions

  • Magnetic Resonance Imaging (MRI) — OTHER
    Enrolled participants will have one MRI during the study on day 2 after having Day 1 visit. During the MRI the participants will complete various tasks.
  • Computer Tasks — BEHAVIORAL
    Eligible participants will complete computer tasks (cognitive tasks, spatial navigation tasks, context dependent fear learning, etc.) at visit 1 and then during the MRI.

Study Details

The way people process and remember information may be related to adverse childhood experiences and Opioid Use Disorder symptoms. The purpose of this project is to examine brain function and performance during learning and memory tasks in adults. The study will compare measures of learning and memory across three groups of participants: those with an Opioid Use Disorder (OUD) that take buprenorphine for opioid replacement therapy, adults without an Opioid Use Disorder taking buprenorphine, and healthy adults that do not have an Opioid Use Disorder and are not taking buprenorphine.

Key Dates

Start date
Jan 9, 2025
Status verified
Dec 2025
Primary completion
Apr 30, 2028
Completion
Apr 30, 2028

Study Design

Enrollment
185 participants (estimated)
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE

Arms

  • Other: Opioid use disorder (OUD) group
    This group takes buprenorphine and has OUD.
  • Other: Buprenorphine (BUP) control group:
    This group takes BUP and does not have OUD.
  • Other: Healthy Controls group
    This group does not take BUP and does not have OUD.

Primary Outcome Measure

Differences in Blood Oxygen Level Dependent (BOLD) signal in the hippocampus [ Time Frame: Day 2 (MRI task visit) ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
University of MichiganAnn ArborMichigan48109
Elizabeth Duval, PhD (PRINCIPAL_INVESTIGATOR)

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By research site
University of Michigan· Ann Arbor, MI

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