Longitudinal Investigation of Sleep, Memory, and Brain Development Across the Nap Transition

Part of paid clinical trials in College Park, Maryland.

Sponsor
University of Maryland, College Park
Study ID
NCT06351098
Status
Recruiting
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Conditions

  • Memory

Eligibility Criteria

Sex
ALL
Age
36 Months - 60 Months
Healthy Volunteers
Accepted

Interventions

  • nap — BEHAVIORAL
    Children are nap promoted

Study Details

To examine the relations between sleep (nap transitions, sleep physiology), memory, and brain development longitudinally, the researchers will assess n=180 children (in order to acquire n=152 usable data sets) who are 36-54 months of age and habitual nappers at enrollment. In each wave, the researchers will assess memory, memory change over a nap and equivalent waking interval, sleep physiology of the nap, and brain structure and function (using Magnetic Resonance Imagining or MRI). Additionally, overnight sleep physiology will be assessed in all participants. Waves will take place approximately every 6 months. For all children, three waves will be collected. With these data, the researchers will address the following aims: * Examine neural markers that predict the sleep transition (Aim 1); * Examine changes in sleep-dependent memory processing (mnemonic discrimination) over both nap and overnight sleep intervals, across the sleep transition (Aim 2); * Examine changes in sleep microstructure in both nap and overnight sleep across the sleep transition (Aim 3) * Examine interrelations among brain, memory and sleep microstructure across the sleep transition (Aim 4)

Key Dates

Start date
Nov 5, 2023
Status verified
Jun 2026
Primary completion
Jun 30, 2028
Completion
Jun 30, 2028

Study Design

Enrollment
180 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: Nap
    Children are nap promoted

Primary Outcome Measure

Memory [ Time Frame: across the nap period, approximately 2.5 hours ]

Locations (2)

FacilityCityStateZIPSite coordinators
University of MarylandCollege ParkMaryland20742
Tracy Riggins, Ph.D.
[email protected]
301-405-5905
Postdoctoral Fellow
[email protected]
301-405-5922
University of MassachusettsAmherstMassachusetts01003
Rebecca MC Spencer, PhD
[email protected]
(413) 577-6128
Postdoctoral Fellow
[email protected]
413-545-4831

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