Detecting Mild Autonomous Cortisol Secretion in Patients With Adrenal Incidentaloma

Part of paid clinical trials in Cleveland, Ohio.

Sponsor
The Cleveland Clinic
Study ID
NCT06344143
Status
Recruiting
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Conditions

  • Mild Autonomous Cortisol Secretion (MACS)

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

  • Various labs and imaging tests — DIAGNOSTIC_TEST
    Dexamethasone Suppression Test, Adrenocorticotropic Hormone (ACTH), Salivary Cortisol Levels, Vasopressin Stimulation test, Fasting Glucose, Fasting Insulin, Complete Metabolic Panel (CMP), Gamma-glutamyl transferase (GGT), Sex Hormone Binding Globulin, Cat scan of abdomen/Pelvis, Whole body dual energy x-ray absorptiometry (DXA) scan, Ultrasound Fibroscan Transient Elastography

Study Details

The aim of the proposed study is to estimate the incidence of Mild Autonomous Cortisol Secretion (MACS) in patients with Adrenal Incidentaloma (AI) and evaluate the available diagnostic tests to determine the most sensitive and specific combination of tests for assessing MACS from adrenal adenoma for prediction of the phenotype associated with cortisol excess. As well as following the patients for 4 years and see if anything changes.

Key Dates

Start date
Nov 20, 2024
Status verified
Jan 2026
Primary completion
Dec 1, 2029
Completion
Dec 31, 2030

Study Design

Enrollment
20 participants (estimated)

Primary Outcome Measure

Evaluate best diagnostic test(s) [ Time Frame: 5 years ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
The Cleveland Clinic FoundationClevelandOhio44195
Maya Boyd
[email protected]
216.444.4919
[email protected]
216-445-4791

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By research site
The Cleveland Clinic Foundation· Cleveland, OH

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