Comparison of Microglial Activation in Severe Asthma and Healthy Controls

Part of paid clinical trials in Madison, Wisconsin.

Sponsor
University of Wisconsin, Madison
Study ID
NCT06299592
Status
Recruiting
Apply to this trial

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - 75 Years
Healthy Volunteers
Accepted

Interventions

  • PET/MRI using [18F]FEPPA tracer — COMBINATION_PRODUCT
    PET/MRI scans with \[18F\]FEPPA radiotracer selective for translocator protein (TSPO) binding, which is elevated in activated microglia

Study Details

The goal of this clinical trial is to learn about how asthma influences brain function. The main questions it aims to answer are: * How airway inflammation in asthma affects the brain; and, * Whether airway inflammation in asthma is related to symptoms of depression and anxiety Over the course of 3 visits, participants will: * Complete questionnaires * Complete computer tasks * Undergo allergy skin test and breathing tests * Give two blood samples * Give a sputum sample * Complete brain imaging scans Researchers will compare results between participants with asthma, and participants who do not have asthma.

Key Dates

Start date
Mar 6, 2024
Status verified
May 2026
Primary completion
Aug 31, 2028
Completion
Aug 31, 2028

Study Design

Enrollment
100 participants (estimated)

Arms

  • Arm: Participants with asthma
  • Arm: Participants without asthma

Primary Outcome Measure

Binding of [18F]-FEPPA [ Time Frame: Up to 2 weeks ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Center for Healthy MindsMadisonWisconsin53703
Janelle Grogan
[email protected]
608-263-0524
Melissa Rosenkranz, PhD (PRINCIPAL_INVESTIGATOR)

Find similar trials in Madison, WI

By condition
Asthma
By specialty
PulmonologyLung disease
By research site
Center for Healthy Minds· Madison, WI

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