Microglia Activation in Asthma

Part of paid clinical trials in Madison, Wisconsin.

Sponsor
University of Wisconsin, Madison
Study ID
NCT04307667
Status
Recruiting
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Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - 75 Years
Healthy Volunteers
Not accepted

Interventions

  • Whole lung antigen challenge (WLAC) — BIOLOGICAL
    Whole lung antigen challenge with cat hair, house dust mite, or short ragweed allergen extracts.
  • [18F]FEPPA — RADIATION
    \[18F\]FEPPA is a radiotracer selective for translocator protein (TSPO) binding, which is elevated in activated microglia.

Study Details

The goal of this clinical trail is to learn about how asthma influences brain function. The main questions it aims to answer are: * How airway inflammation in asthma affects the brain; and, * Whether airway inflammation in asthma is related to symptoms of depression and anxiety Over the course of 6 visits, participants will: * Complete questionnaires * Complete computer tasks * Undergo allergy skin test * Undergo breathing tests including two whole lung allergen challenges * Give four blood samples * Complete brain imaging scans

Key Dates

Start date
Dec 17, 2019
Status verified
May 2026
Primary completion
Aug 1, 2028
Completion
Aug 1, 2028

Study Design

Enrollment
50 participants (estimated)

Primary Outcome Measure

Presence of Neuroinflammation measured by TSPO observed via PET scan [ Time Frame: up to 9 days ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
University of Wisconsin MadisonMadisonWisconsin53703-2637
Melissa Rosenkranz, PhD (PRINCIPAL_INVESTIGATOR)

Find similar trials in Madison, WI

By condition
Asthma
By specialty
PulmonologyLung disease
By research site
University of Wisconsin Madison· Madison, WI

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