Effect of Raised End-Tidal pCo2 on Choroidal Volume

Part of paid clinical trials in Pittsburgh, Pennsylvania.

Sponsor
University of Pittsburgh
Study ID
NCT06275308
Status
Recruiting
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Conditions

  • Intraocular Pressure

Eligibility Criteria

Sex
ALL
Age
N/A - 8 Years
Healthy Volunteers
Accepted

Interventions

  • Ventilation manipulation — OTHER
    Effects of ventilation manipulation to achieve desired levels of end tidal carbon dioxide

Study Details

This study is to investigate the relationship between arterial carbon dioxide (CO2) concentration and vitreous pressure on the choroidal volume by integrated intraoperative OCT imaging under eye exams under anesthesia.

Key Dates

Start date
Feb 27, 2023
Status verified
Jan 2026
Primary completion
Dec 30, 2026
Completion
Dec 30, 2026

Study Design

Enrollment
20 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: Observational Group
    Manipulation of end tidal carbon dioxide in subjects

Primary Outcome Measure

Intraocular Pressure (IOP) (mmHg) [ Time Frame: After induction of anesthesia end tidal CO2 will be manipulated to 40mmHg, then 30mmHg and then 50mmHg. The end tidal CO2 levels will be held for at least 5 minutes after each ventilation manipulation and at the end of this 5 minute period IOP measured ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
University of Pittsburgh Medical CenterPittsburghPennsylvania15224
Amy Monroe, MPH, MBA
[email protected]
Kanwal Nischal, MD,FRCOphth (PRINCIPAL_INVESTIGATOR)
Lieu Tran, MD (SUB_INVESTIGATOR)

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By research site
University of Pittsburgh Medical Center· Pittsburgh, PA

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