External Influences Upon Ocular Homeostasis

Part of paid clinical trials in Nashville, Tennessee.

Sponsor
Vanderbilt University Medical Center
Study ID
NCT00338065
Status
Enrolling By Invitation

Conditions

  • Intraocular Pressure

Eligibility Criteria

Sex
ALL
Age
10 Years - 90 Years
Healthy Volunteers
Accepted

Interventions

  • Postural change — BEHAVIORAL
    Intraocular pressures, blood pressures, and retinal thicknesses are measured with postural changes
  • Water drinking — BEHAVIORAL
    Intraocular pressures, blood pressures, and retinal thicknesses are measured with water drinking.

Study Details

Our experiments are designed to test the overall hypothesis that position-dependent or water-dependent intra-ocular pressure (IOP) spikes occur in humans, and that these challenge ocular homeostasis.

Key Dates

Start date
Jun 30, 2006
Status verified
Dec 2025
Primary completion
Dec 31, 2027
Completion
Dec 31, 2027

Study Design

Enrollment
200 participants (estimated)
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: Subjects with autonomic dysfunction
    Subjects with known autonomic dysfunction diagnoses as defined by the General Clinical Research Center (GCRC) such as pure autonomic failure, Postural orthostatic tachycardia syndrome (POTS), and Multiple System Atrophy( MSA). 1. Intraocular pressures, blood pressures, and retinal thicknesses are measured with postural changes 2. Intraocular pressures, blood pressures, and retinal thicknesses are measured with water drinking.
  • Experimental: Primary open-angle glaucoma subjects
    Subjects diagnosed with primary open-angle glaucoma following a glaucoma specialist's examination. 1. Intraocular pressures, blood pressures, and retinal thicknesses are measured with postural changes 2. Intraocular pressures, blood pressures, and retinal thicknesses are measured with water drinking.
  • Experimental: Subjects with normal-pressure glaucoma
    Subjects with open-angle glaucoma damage following a glaucoma specialist's examination without ever an intraocular pressure recording greater than 21 mm Hg. .1. Intraocular pressures, blood pressures, and retinal thicknesses are measured with postural changes 2\. Intraocular pressures, blood pressures, and retinal thicknesses are measured with water drinking.
  • Active Comparator: Normal subjects
    Subjects without evidence of glaucoma or autonomic dysfunction. ..1. Intraocular pressures, blood pressures, and retinal thicknesses are measured with postural changes 2\. Intraocular pressures, blood pressures, and retinal thicknesses are measured with water drinking.

Primary Outcome Measure

Change in Intraocular Pressure [ Time Frame: Within 1 day ]

Locations (1)

FacilityCityStateZIPSite coordinators
Vanderbilt UniversityNashvilleTennessee37232-

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