Enhancing Transdiagnostic Mechanisms of Cognitive Dyscontrol (R33)

Conditions

• Anxiety Disorders
• Depression
• Post Traumatic Stress Disorder

Eligibility Criteria

Sex

ALL

Age

21 Years - 55 Years

Healthy Volunteers

Not accepted

Interventions

• COGENT — BEHAVIORAL
  COGENT is based on a working memory capacity task, which requires individuals to memorize stimuli while simultaneously completing a secondary puzzle task.
• Sham Program — OTHER
  The Sham Program will be a similar task which researchers think will be less effective in training thinking skills.

Study Details

The proposed project aims to test the cognitive and neural effects of a cognitive training in a sample of individuals seeking treatment for anxiety, depression, or traumatic stress symptoms. Participants will be randomly assigned to one of two groups. Group 1 will receive a computer-based program that is designed as a cognitive training intervention and Group 2 will receive a similar computer-based exercise that researchers think will be less effective in training thinking skills (also known as a control or sham condition). Participants will be compared on cognitive performance and brain response during cognitive tasks from baseline to post-treatment.

Key Dates

Start date

Oct 1, 2024

Status verified

Oct 2025

Primary completion

Jun 1, 2027

Completion

Aug 1, 2027

Study Design

Enrollment

128 participants (estimated)

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Arms

• Experimental: COGENT - Cognitive Training Intervention Program
  Computer-administered cognitive training program. COGENT is a modified working memory capacity task designed to train cognitive functioning. COGENT was designed to contain high interference across trials. By requiring repeated practice with utilization of interference control across trials, COGENT is thought to enhance plasticity of cognitive systems and improve performance. That is, training is based on the premise that learning-based neural changes will occur via repeated exposure to a task demanding cognitive control resources
• Sham Comparator: Non-Training Program
  The non-training condition requires participants to complete a similar computer task for the same length of time. The non-training is a modified working memory capacity task designed to be inert. The non-training condition was designed to contain relatively less interference demands across trials.

Primary Outcome Measure

Change in cognitive performance [ Time Frame: Baseline, Week 4, Week 8, Week 16 ]

Central Contacts

• Jessica Bomyea, Ph.D.
  858.552.8585
  [email protected]

Locations (1)

Find similar trials in San Diego, CA

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