Dupixent in Adults With Refractory Post-Burn Pruritus in an Ambulatory Clinic

Conditions

The goal of this study is to test the efficacy of Dupixent in improving post-burn itching symptoms versus the current standard of care.

Active Comparator: ARM 1 - Dupixent
Two subcutaneous injection of 300mg Dupixent at visit 1 and every two weeks (+/- 2 days) for a total of 6 administrations. Injections may be administered in the thigh, lower abdomen or upper arm. The initial dose (two 300 mg doses) will be given in two different injection sites. There are not restriction or guidance regarding dose administration related to meals. No dose modifications will occur during study participation.
Placebo Comparator: ARM 2 - Placebo
Two subcutaneous injection of the placebo at visit 1 and every two weeks (+/- 2 days) for a total of 6 administrations. Injections may be administered in the thigh, lower abdomen or upper arm. The initial dose (two doses) will be given in two different injection sites. There are not restriction or guidance regarding dose administration related to meals. No dose modifications will occur during study participation.

Itch Severity Scale (ISS) Scores [ Time Frame: 12 WEEKS ]

Facility	City	State	ZIP	Site coordinators
Akron Children's Hospital	Akron	Ohio	44308	Anjay Khandelwal, MD [email protected] 330-543-4649 Jessica Kracker, BSN [email protected] 330-543-0846 Anjay Khandelwal, MD (PRINCIPAL_INVESTIGATOR) Richard Lou, MD (SUB_INVESTIGATOR)

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