Perceptions of E-Cigarettes and Synthetic Cooling Agents, The ICE Study

Conditions

• Abuse Tobacco
• Exposure

Eligibility Criteria

Sex

ALL

Age

21 Years - 29 Years

Healthy Volunteers

Accepted

Interventions

• Behavioral Intervention — BEHAVIORAL
  Receive and use flavored e-cigarettes (EC) as directed
• Biospecimen Collection — OTHER
  Undergo biosample sample collection
• Survey Administration — OTHER
  Complete surveys

Study Details

This study evaluates how synthetic cooling additives like WS-3 and WS-23 impact e-cigarette perceptions, use behavior, and toxicant exposure.

Key Dates

Start date

May 8, 2024

Status verified

Feb 2026

Primary completion

Dec 31, 2027

Completion

Jun 30, 2028

Study Design

Enrollment

300 participants (estimated)

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

HEALTH_SERVICES_RESEARCH

Arms

• Active Comparator: Fruit flavored e-cigarette with synthetic cooling agents added
  Synthetic cooling agents will be added to fruit flavored e-liquid for this condition.
• Active Comparator: Fruit flavored e-cigarette
  Fruit flavored e-liquid will be used for this condition.
• Active Comparator: Tobacco flavored e-cigarette with synthetic cooling agents added
  Synthetic cooling agents will be added to tobacco flavored e-liquid for this condition.
• Active Comparator: Tobacco flavored e-cigarette
  Tobacco flavored e-liquid will be used for this condition.

Primary Outcome Measure

Satisfaction and psychological reward [ Time Frame: Minute 5 of vaping session, Minute 35 of vaping session ]

Central Contacts

• The Ohio State Comprehensive Cancer Center
  800-293-5066
  [email protected]

Locations (1)

Find similar trials in Columbus, OH