Metformin and Muscle Recovery

Part of paid clinical trials in Salt Lake City, Utah.

Sponsor
University of Utah
Study ID
NCT06185179
Phase
EARLY_PHASE1
Status
Recruiting
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Conditions

  • Muscle Atrophy or Weakness

Eligibility Criteria

Sex
ALL
Age
60 Years - N/A
Healthy Volunteers
Accepted

Interventions

  • Metformin — DRUG
    Metformin will be distributed in 500mg pills.
  • Placebo — OTHER
    Placebo will be distributed in pill form

Study Details

A hallmark of aging is an impaired ability to adequately recover following a stressor, such as muscle disuse, resulting in muscle fibrosis and weakness thereby increasing the risk for falls and loss of independence. Mechanistic-based therapeutic strategies to enhance muscle recovery in older adults do not exist. Metformin has been implicated to have positive effects on muscle size and function through non-glycemic mechanisms. Metformin has been shown to enhance macrophage function and lessen cellular senescence burden by targeting SASP in a variety of muscle interstitial cells. However, the role of metformin to improve muscle recovery in older adults following disuse atrophy through immunomodulating and senomorphic mechanisms have not been examined. Therefore, the purpose of this study is to conduct a randomized, double blind, placebo-controlled clinical trial in older adult participants to determine if short-term metformin delivery (vs placebo) during the recovery phase following disuse atrophy can improve muscle regrowth.

Key Dates

Start date
Sep 1, 2024
Status verified
Dec 2025
Primary completion
May 31, 2029
Completion
May 31, 2030

Study Design

Enrollment
50 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: Metformin
    Metformin pills will be given orally and daily during the 2-week recovery period following single leg immobilization Metformin will be titrated up to a dose 2g/day. 1g dose (two 500 mg pills) will be taken in the morning and a 1g dose will be taken in the evening. This will take place over each day for 14 days during the recovery period.
  • Placebo Comparator: Placebo
    Placebo pills will be given orally and daily during the 2-week recovery period following single leg immobilization. Two pills will be taken in the morning and two pills will be taken in the evening. This will take place over each day for 14 days during the recovery period.

Primary Outcome Measure

% recovery of thigh muscle volume (TMV) [ Time Frame: Thigh muscle volume will be determined at 14 days of single leg immobilization and at 14 days of recovery. ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
University of UtahSalt Lake CityUtah84112
Micah Drummond, PhD
[email protected]
8012132737
Rebekah Drummond
[email protected]
8018394524

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By research site
University of Utah· Salt Lake City, UT

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