C-Protein in Fatigue and Aging

Part of paid clinical trials in Eugene, Oregon.

Sponsor
University of Oregon
Study ID
NCT05926219
Status
Recruiting
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Conditions

  • Aging
  • Muscle Atrophy or Weakness
  • Sarcopenia
  • Sarcopenia in Elderly

Eligibility Criteria

Sex
ALL
Age
18 Years - 80 Years
Healthy Volunteers
Accepted

Interventions

  • Fatiguing Exercise — BEHAVIORAL
    Volunteers will perform knee extension exercise of the dominant limb while seated in a chair designed for exercise of the knee extensor muscle group. The chair will be equipped with a lever arm, aligned with the axis of rotation of the knee and fixed to the distal shank, 2 centimeters proximal to the ankle joint. The lever arm will be instrumented to provide resistance and measure velocity. The volunteers will perform 3-5 maximum voluntary contractions (MVC) to determine peak torque. Once established, volunteers will rest for 5 minutes before initiating the fatigue protocol, whereby they will perform repeated MVC of the dominant limb against resistance equal to or less than 50% of MVC until range of motion cannot be maintained. Because the goal of this exercise is to uniformly fatigue the quadriceps muscle group, this exercise will be performed continuously. It is expected to take between 1 and 3 minutes to achieve the desired level of fatigue.

Study Details

This study is investigating changes to the proteins in skeletal muscle that contribute to reduced muscle size and muscle function that occurs with aging.

Key Dates

Start date
Nov 6, 2017
Status verified
Jan 2025
Primary completion
Jan 31, 2027
Completion
Jan 31, 2027

Study Design

Enrollment
24 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: Fatigue
    Volunteers will perform one-legged knee extension exercise until fatigue while seated on an ergometer. Volunteers will then undergo bilateral skeletal muscle biopsies of the vastus lateralis muscle in their thigh.

Primary Outcome Measure

Phosphorylation of myosin binding protein c (MyBP-C) [ Time Frame: One week after the participant undergoes the biopsies. ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
University of OregonEugeneOregon97403
Damien M Callahan, Ph.D.
[email protected]
458-205-5343
Damien M Callahan, Ph.D. (PRINCIPAL_INVESTIGATOR)

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By research site
University of Oregon· Eugene, OR

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