FDG PET/MR Imaging of Peripheral Pain Generators

Part of paid clinical trials in Madison, Wisconsin.

Sponsor
University of Wisconsin, Madison
Study ID
NCT06171659
Status
Recruiting
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Conditions

  • Nociceptive Pain
  • Pain

Eligibility Criteria

Sex
ALL
Age
18 Years - 85 Years
Healthy Volunteers
Accepted

Interventions

  • FDG radiotracer — DRUG
    Fludeoxyglucose F 18 Injection is a positron emitting radiopharmaceutical containing no-carrier added radioactive 2-deoxy-2-\[18F\]fluoro-D-g1ucose, which is used for diagnostic purposes in conjunction with Positron Emission Tomography (PET). It is administered by intravenous injection. Dosage planned 0.14 mCi/kg/patient.
  • PET/MRI — DEVICE
    positron emission tomography and magnetic resonance imaging
  • PET/CT imaging — DEVICE
    positron emission tomography and computed tomography imaging

Study Details

The purpose of this research is to determine if a PET/MRI scan using FDG can accurately identify the source of chronic pain. Identifying the source of pain may help doctors treat chronic pain more effectively. Approximately 128 participants will be enrolled and can expect to be on study for up to 12 months.

Key Dates

Start date
Nov 19, 2024
Status verified
Sep 2025
Primary completion
Jun 30, 2027
Completion
Jun 30, 2027

Study Design

Enrollment
128 participants (estimated)

Arms

  • Arm: Open Surgical Procedure (Arthroplasty)
    PPSP subjects who have undergone hip (or knee) joint arthroplasty (i.e., open surgical procedure for joint replacement). * 6 month post-op scans * 12 month post-op scans * 18 month post-op scans
  • Arm: Less Invasive Procedure (Arthroscopy)
    PPSP subjects who have undergone hip (or knee) arthroscopy (i.e., less invasive joint surgical procedure involving scopes and lower profile surgical tools) \- 6 month post-op scans
  • Arm: Asymptomatic: Had Total Joint Replacement (Arthroplasty)
    Asymptomatic subjects who have undergone total hip or total knee arthroplasty. \- single scan during one study visit (up to 3.5 hours)
  • Arm: Asymptomatic: Less Invasive Procedure (Arthroscopy)
    Asymptomatic subjects who have undergone hip or knee arthroscopy. \- single scan during one study visit (up to 3.5 hours)

Primary Outcome Measure

Change in SUVmax (chronic pain) [ Time Frame: baseline (6 months post-op), 12 months post-op, 18 months post-op ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
UW School of Medicine and Public HealthMadisonWisconsin53792-

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