Voice Quality Analysis of Patients With Laryngotracheal Stenosis
Part of paid clinical trials in Baltimore, Maryland.
- Sponsor
- Johns Hopkins University
- Study ID
- NCT06161077
- Status
- Not Yet Recruiting
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Conditions
- Idiopathic Subglottic Tracheal Stenosis
Eligibility Criteria
- Sex
- ALL
- Age
- 18 Years - 80 Years
- Healthy Volunteers
- Not accepted
Interventions
- Voice Biomarker Screening Too — DIAGNOSTIC_TESTThe investigators will develop a screening tool using voice that can predict disease severity in idiopathic subglottic stenosis
Study Details
The investigators previously demonstrated that voice changes are common in patients with Laryngotracheal Stenosis (LTS), and patients typically report an improvement in voice outcomes following endoscopic dilation. Recently, NIH based programs such as a Bridge to Artificial Intelligence (Bridge2AI) have highlighted the use of artificial intelligence to identify acoustic biomarkers of disease. Therefore, the investigators hypothesize that progression of LTS scar can be quantified using acoustic measurements and machine learning. The goal of this clinical trial is to remotely monitor patient voice quality in an effort to determine if regularly performed voice recordings can be used as a diagnostic tool in order to predict the need for dilation procedures. The investigators feel that successful use of remote voice recording technology with algorithmic analysis will improve patient quality of life.
Key Dates
- Start date
- Jul 1, 2026
- Status verified
- Aug 2025
- Primary completion
- Jul 1, 2028
- Completion
- Dec 1, 2028
Study Design
- Enrollment
- 100 participants (estimated)
Primary Outcome Measure
Voice Quality in patients with idiopathic subglottic stenosis [ Time Frame: Baseline, 14 days, monthly for 2 years ]
Central Contacts
- Samuel L Collins, Ph.D.4107020420
Locations (1)
| Facility | City | State | ZIP | Site coordinators |
|---|---|---|---|---|
| Johns Hopkins Outpatient Center | Baltimore | Maryland | 21287 | Alexander Hillel, MD (PRINCIPAL_INVESTIGATOR) |