TMS for Inhibition Enhancement in Schizophrenia

Part of paid clinical trials in Catonsville, Maryland.

Sponsor
University of Maryland, Baltimore
Study ID
NCT06155682
Status
Recruiting
Apply to this trial

Conditions

Eligibility Criteria

Sex
ALL
Age
18 Years - 45 Years
Healthy Volunteers
Not accepted

Interventions

  • repetitive transcranial magnetic stimulation (active) — DEVICE
    non-invasive active repetitive stimulation applied to the scalp surface
  • repetitive transcranial magnetic stimulation (sham) — DEVICE
    non-invasive active repetitive stimulation applied to the scalp surface

Study Details

This study purpose is to perform a pilot mechanistic trial repetitive transcranial magnetic stimulation (rTMS) clinical trial in 34 people with schizophrenia (Sz). The trial will evaluate whether inhibitory 1 Hertz (Hz) rTMS targeting motor cortex can increase brain inhibition reflected in a decrease in the short-interval intracortical inhibition (SICI) score from pre-to-post-treatment. We will also collect preliminary data on the effect of rTMS on the resting functional connectivity of the motor cortex and other brain regions and the relationship of change in SICI to change in cognitive performance

Key Dates

Start date
Feb 2, 2026
Status verified
Feb 2026
Primary completion
Mar 31, 2029
Completion
Apr 30, 2029

Study Design

Enrollment
34 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER

Arms

  • Active Comparator: Active rTMS
    multiple trains of active transcranial magnetic stimulation in a day (using the active TMS coil), for multiple days
  • Sham Comparator: sham rTMS
    multiple trains of sham transcranial magnetic stimulation in a day (using the sham comparator TMS coil), for multiple days

Primary Outcome Measure

The change in the short interval intracortical inhibition (SICI) score [ Time Frame: one week ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Maryland Psychiatric Research CenterCatonsvilleMaryland21228
Stephanie M Hare, PhD
[email protected]
410-402-6119

Find similar trials in Catonsville, MD

By condition
Schizophrenia
By specialty
PsychiatryMental healthBehavioral health
By research site
Maryland Psychiatric Research Center· Catonsville, MD

Related Studies