Evaluation of Gastric Content of Volunteers Fasting and Using Semaglutide: an Observational and Cross-sectional Study

Sponsor
Hospital Israelita Albert Einstein
Study ID
NCT06154486
Status
Completed

Conditions

  • Anesthesia
  • Pneumonia, Aspiration

Eligibility Criteria

Sex
ALL
Age
18 Years - N/A
Healthy Volunteers
Not accepted

Interventions

Study Details

Medicines with peptide-1 receptor agonist action similar to glucagon (GLP-1) are a modern therapeutic option for obesity and diabetes mellitus. Semaglutide is a representative of this class medication whose mechanism of action can result in the slowing of gastric emptying and reduced gastric motility, a scenario that can increase the risk of pulmonary aspiration in individuals undergoing anesthesia and despite adequate fasting. Given the severity of the occurrence of bronchoaspiration, the action biological analysis of GLP-1 analogues on gastric function and incremental use of these medications, through gastric ultrasound, we will aim to evaluate the gastric contents of volunteers who do not have risk factors for bronchoaspiration, who will not undergo anesthesia, but are with the fasting recommended for this purpose and are using semaglutide, an analogue of GLP-1. Our hypothesis is that the majority of individuals using these medications have a full stomach even during fasting times recommended in the literature. In view of this, for this population we must adapt safety criteria during the anesthetic procedure.

Key Dates

Start date
Jun 19, 2023
Status verified
Sep 2023
Primary completion
Jun 19, 2023
Completion
Aug 22, 2023

Study Design

Enrollment
30 participants (actual)

Arms

  • Arm: semaglutide group
    patients without risk factors for gastroparesis, fasting for at least 8 hours, BMI less than 30 and currently using semaglutide
  • Arm: control group
    patients without risk factors for gastroparesis, fasting for at least 8 hours, BMI less than 30 and who have never used semaglutide or another GLP-1 analogue

Primary Outcome Measure

prevalence of full stomach after fasting for at least 8 hours [ Time Frame: 1 day ]

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