Effect of Visual Retraining After Stroke

Part of paid clinical trials in Rochester, New York.

Sponsor
University of Rochester
Study ID
NCT06121219
Status
Recruiting
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Conditions

  • Cortical Blindness
  • Hemianopia
  • Hemianopia Homonymous
  • Quadrantanopia
  • Stroke - Occipital Infarction
  • Stroke, Ischemic
  • Vision Loss Partial
  • Vision; Loss, Both Eyes

Eligibility Criteria

Sex
ALL
Age
21 Years - 80 Years
Healthy Volunteers
Accepted

Interventions

  • Training in the Blind Field — DEVICE
    A computer software and chin-rest necessary to perform visual training will be loaned to each subject to be used at home. Subjects will perform one to two daily training sessions in their home, consisting of 200-300 trials each. The visual task performed repetitively will involve discriminating the direction of motion, the presence of motion, or the orientation of a visual stimulus (either a small cloud of dots or bars) located at a predetermined location in the blind field. The computer program will automatically create a record of patient performance during each home training session. Subjects will train daily (about 40-60 minutes total), 5 to 7 days per week for at least 3 and up to 12 months at a time.

Study Details

This project is intended to collect data using standard clinical tests and psychophysics to quantify the effect of visual cortical damage on the structure of the residual visual system, visual perception, spatial awareness, and brain function. The investigators will also assess the effect of intensive visual retraining on the residual visual system, processing of visual information and the use of such information in real-world situations following damage. This research is intended to improve our understanding of the consequences of permanent visual system damage in humans, of methods that can be used to reverse visual loss, and of brain mechanisms by which visual recovery is achieved.

Key Dates

Start date
Sep 5, 2024
Status verified
Jul 2025
Primary completion
Jan 31, 2030
Completion
Jan 31, 2032

Study Design

Enrollment
100 participants (estimated)
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT

Arms

  • Experimental: Experimental: Cortically Blind (CB) Subjects
    Cortically Blind subjects will be enrolled to perform a daily home visual training task.
  • No Intervention: Normative Comparator: Control Subjects
    Healthy control subjects will be recruited to collect normative data by which to compare test results from CB subjects. No home training will be asked.

Primary Outcome Measure

Change in Mean Direction Discrimination Threshold [ Time Frame: Baseline to 4-6 months ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
University of Rochester Medical CenterRochesterNew York14642
Evan Burr, BA
[email protected]
585-275-5423
Krystel R Huxlin, PhD (PRINCIPAL_INVESTIGATOR)

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University of Rochester Medical Center· Rochester, NY

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