Cerebellar Involvement in Cognitive Sequencing

Conditions

• Effects of Cerebellar Stimulation on Brain Activation

Eligibility Criteria

Sex

ALL

Age

18 Years - 50 Years

Healthy Volunteers

Accepted

Interventions

• TMS during sequence-demanding task — PROCEDURE
  TMS is administered during the execution of sequence-demanding task. Transcranial magnetic stimulation (TMS) is a safe and non-invasive technique for transiently modulating brain activity
• No TMS during sequence-demanding task — PROCEDURE
  TMS is not administered during the execution of sequence-demanding task.
• TMS during non-sequence-demanding task — PROCEDURE
  TMS is administered during the execution of non-sequence-demanding task. Transcranial magnetic stimulation (TMS) is a safe and non-invasive technique for transiently modulating brain activity
• No TMS during non-sequence-demanding task — PROCEDURE
  TMS is not administered during the execution of non-sequence-demanding task

Study Details

Although there is increasing recognition that the cerebellum is involved in cognition as well as motor function, the manner in which the cerebellum contributes to cognition is uncertain. One theory that might account for both motor and cognitive contributions of the cerebellum is that the cerebellum is involved in sequencing of relevant events or stimuli. Previous experiments have suggested that disruption of the cerebellum impairs the prediction of the next event in a sequence. The present experiment will examine the impact of cerebellar stimulation on brain activation during the performance of both sequence-demanding and non-sequence-demanding tasks.

Key Dates

Start date

Mar 1, 2024

Status verified

Jan 2026

Primary completion

Jul 31, 2026

Completion

Jul 31, 2027

Study Design

Enrollment

50 participants (estimated)

Allocation

NON_RANDOMIZED

Intervention model

PARALLEL

Primary purpose

BASIC_SCIENCE

Arms

• Experimental: Cerebellar Stimulation
  TMS will be administered to the cerebellum on half the trials of a sequence-demanding task, and on half the trials of a non-sequence-demanding task. Task order will be counterbalanced.
• Active Comparator: Occipital Stimulation
  TMS will be administered to an occipital control region on half the trials of a sequence-demanding task, and on half the trials of a non-sequence-demanding task. Task order will be counterbalanced.

Primary Outcome Measure

functional magnetic resonance imaging brain activation [ Time Frame: during scan up to 1 hour ]

Central Contacts

• John E Desmond, Ph.D.
  410-502-3583
  [email protected]
• JoAnna Mathena, MS
  443-571-0947
  [email protected]

Locations (1)

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