Effect of Gerofit Exercise on Cognition in Older Veterans

Part of paid clinical trials in West Los Angeles, California.

Sponsor
VA Office of Research and Development
Study ID
NCT06107842
Status
Recruiting
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Conditions

  • Aging
  • Cognitive Impairment
  • Physical Activity

Eligibility Criteria

Sex
ALL
Age
65 Years - N/A
Healthy Volunteers
Accepted

Interventions

  • Gerofit exercise — BEHAVIORAL
    Individualized exercise prescription as well as a group exercise class based on physical function assessments offered 3x/week
  • Health education — BEHAVIORAL
    Scheduled monthly in-person health education discussion sessions covering 12 different health topics not including a physical activity/exercise promotion session

Study Details

Over 50% of the Veterans enrolled for VA health care are over the age of 65. Dementia prevalence increases with age, and with the increase in the population of people ages 65 and older, the total number of people with dementia is also increasing. Older Veterans often have comorbid PTSD, major depression and traumatic brain injury so that they are at 2 to 5 times the risk for cognitive impairment and dementia compared to the general population. There is evidence that exercise interventions in sedentary older adults could improve both physical and cognitive function. However, there have been very few studies on the effects of exercise on cognition in older Veterans and do not reflect the broader ethnic and health-status diversity of Veterans. Thus, improved knowledge of the role of exercise on cognition as well as the predictive power of biomarkers could have a major beneficial impact on Veterans' functional independence and quality of life. The investigators hypothesize that participation in the VA Gerofit exercise program will improve cognitive function in older Veterans and that blood and muscle biomarkers will predict these improvements.

Key Dates

Start date
Apr 1, 2024
Status verified
May 2026
Primary completion
Sep 30, 2028
Completion
Mar 31, 2029

Study Design

Enrollment
150 participants (estimated)
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION

Arms

  • Active Comparator: Gerofit exercise
    Participants enrolled in the Gerofit program
  • Placebo Comparator: Health education
    Participants enrolled in monthly in-person health education sessions which do not include a physical activity/exercise promotion session

Primary Outcome Measure

Memory composite score [ Time Frame: Change from baseline at 3 months ]

Central Contacts

Locations (2)

FacilityCityStateZIPSite coordinators
VA Greater Los Angeles Healthcare System, West Los Angeles, CAWest Los AngelesCalifornia90073-1003
Irma Gvilia, PhD MS
[email protected]
(818) 891-7711
Cathy C Lee, MD (PRINCIPAL_INVESTIGATOR)
Jonathan M Wanagat, MD PhD (PRINCIPAL_INVESTIGATOR)
Stacy Wilkins, PhD (PRINCIPAL_INVESTIGATOR)
Baltimore VA Medical Center VA Maryland Health Care System, Baltimore, MDBaltimoreMaryland21201
Rhianna Patel
[email protected]
443-421-5833
Steven J Prior, PhD
[email protected]
3014052483

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By research site
VA Greater Los Angeles Healthcare System, West Los Angeles, CA· West Los Angeles, CABaltimore VA Medical Center VA Maryland Health Care System, Baltimore, MD· Baltimore, MD

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