Spectral Lighting and Intestinal Failure

Conditions

• Intestinal Failure

Eligibility Criteria

Sex

ALL

Age

N/A - 1 Year

Healthy Volunteers

Not accepted

Interventions

• Spectral Lighting — OTHER
  Spectral room lighting containing violet and blue wavelengths of light capable of stimulating non-visual opsins including OPN5 and OPN3.

Study Details

The goal of this exploratory n-of-1-study is to compare markers of metabolism in infants with intestinal failure between two lighting environments. Investigators are seeking to learn whether supplementing the lighting environment of infants with intestinal failure with blue and violet wavelengths of light will allow more efficient utilization of the nutrition provided to participants by influencing hormones involved in regulation of growth and development as compared to a conventional lighting environment. Pre-clinical studies suggest that violet and blue wavelengths of light are involved in molecular pathways that help regulate metabolic activity.

Key Dates

Start date

Mar 1, 2024

Status verified

Dec 2024

Primary completion

Sep 15, 2026

Completion

Mar 15, 2027

Study Design

Enrollment

32 participants (estimated)

Allocation

NA

Intervention model

SINGLE_GROUP

Primary purpose

BASIC_SCIENCE

Arms

• Experimental: Lighting cycling (Spectral vs Conventional)
  The study protocol will commence the Monday after study subject enrollment, if medically feasible, and will consist of four weeks of alternating periods of 3 days of daytime conventional (CON) hospital lighting followed by 4 days of daytime full spectrum lighting (FS) including violet and blue light wavelengths.

Primary Outcome Measure

plasma protein concentration of insulin [ Time Frame: For four weeks, once a week for each lighting condition and once a week during the predawn hours after each lighting condition, for a total of four samples per week. ]

Locations (1)

Find similar trials in Cincinnati, OH

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