Speech-in-noise Perception in Autism and Fragile X

Part of paid clinical trials in Cincinnati, Ohio.

Sponsor
Children's Hospital Medical Center, Cincinnati
Study ID
NCT06088589
Status
Recruiting
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Conditions

Eligibility Criteria

Sex
ALL
Age
15 Years - 35 Years
Healthy Volunteers
Accepted

Interventions

  • Mismatch negativity — BEHAVIORAL
    Event related potentials are compared between frequent and infrequent speech sounds (i.e., "ba" vs "da").

Study Details

The goal of this study is to identify which brain regions are active during speech-in-noise perception, as well as how those regions interact. The investigators are studying brain activation during speech-in-noise in autism and controls as well as individuals with Fragile X Syndrome. The main question\[s\] it aims to answer are: 1) How does the brain's response to background noise affect a person's ability to understand speech? 2) Can visual cues improve hearing in background noise? Participants will complete the following: * hearing tests * cognitive and behavioral measures * questionnaires about their symptoms * both passive and active hearing tasks while brain activity is recorded with a neuroimaging cap Results will be compared between individuals with autism with and without Fragile X Syndrome as well as individuals without autism.

Key Dates

Start date
Nov 10, 2023
Status verified
Mar 2026
Primary completion
Apr 30, 2026
Completion
Apr 30, 2026

Study Design

Enrollment
60 participants (estimated)
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE

Arms

  • Experimental: Speech Sounds
    Participants will hear repeated speech sounds while wearing a neuroimaging cap.

Primary Outcome Measure

Speech reception threshold for single digits in noise- auditory only [ Time Frame: Baseline ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Cincinnati Children'S HospitalCincinnatiOhio45229-3026
Elizabeth Smith
[email protected]

Find similar trials in Cincinnati, OH

By condition
Autism spectrum disorder
By specialty
Pediatrics
By research site
Cincinnati Children'S Hospital· Cincinnati, OH

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