Prognostic Value of Hyperpolarized 13C MRI for Clinical Myocardial Viability

Part of paid clinical trials in Dallas, Texas.

Sponsor
University of Texas Southwestern Medical Center
Study ID
NCT06047028
Status
Recruiting
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Conditions

  • Coronary Artery Disease
  • Ischemic Heart Disease (IHD)
  • Myocardial Viability

Eligibility Criteria

Sex
ALL
Age
20 Years - 80 Years
Healthy Volunteers
Accepted

Study Details

Heart failure due to coronary artery disease represents a significant cause of mortality. The detection of patients eligible for bypass surgery is a pivotal concern. Nevertheless, the optimal approach for patient selection based on conventional imaging scans remains unclear. The proposed method (Hyperpolarized 13C MRI) has gained extensive use in evaluating in vivo metabolism. This method avoids ionizing radiation and provides critical insights into cardiac function. The feasibility study aims to investigate this method for patient selection before bypass surgery. This innovative imaging technique facilitates the identification of two simple molecules, bicarbonate and lactic acid, produced at high rates by normal heart metabolism. Both bicarbonate and lactate originate from the same precursor molecule, pyruvate. The data generated from this study holds the potential to refine diagnostic precision.

Key Dates

Start date
Jun 30, 2023
Status verified
Feb 2026
Primary completion
Jun 30, 2026
Completion
Jun 30, 2026

Study Design

Enrollment
30 participants (estimated)

Arms

  • Arm: Healthy Control Subjects
    Healthy volunteers (male or female, aged 20-80 years) who are eligible for a 3T MRI. They must have no history of coronary artery disease, diabetes, or other exclusionary medical diagnoses.
  • Arm: Preoperative CAD Patients
    Male or female patients (aged 20-80 years) who are scheduled for Coronary Artery Bypass Surgery as standard of care. These patients have 1, 2, or more stenotic coronary vessels and are eligible for a 3T MRI.
  • Arm: Postoperative CAD Patients
    The same population of patients from the preoperative group undergoing a follow-up evaluation 4-6 months after their surgical coronary revascularization.

Primary Outcome Measure

Bicarbonate-to-Lactate Ratio in Healthy Control Subjects [ Time Frame: Baseline (Day 1 of imaging) ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
University of Texas Southwestern Medical CenterDallasTexas75390
Sarah S McNeil, RN
[email protected]
214-645-7700

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By research site
University of Texas Southwestern Medical Center· Dallas, TX

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