Cognitive and Vascular Functioning Following TBI

Part of paid clinical trials in Bethesda, Maryland.

Sponsor
Walter Reed National Military Medical Center
Study ID
NCT06034509
Status
Recruiting
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Conditions

  • Cognitive Decline
  • Traumatic Brain Injury
  • Vascular Dementia

Eligibility Criteria

Sex
ALL
Age
18 Years - 74 Years
Healthy Volunteers
Not accepted

Interventions

  • No intervention. This is an observational study. — OTHER
    There are no interventions being tested in the Cognitive and Vascular Functioning Following TBI study.

Study Details

This observational study will examine the association of chronic traumatic cerebrovascular injury and cardiovascular risk factors with TBI-related cognitive impairment and vascular dementia. Cerebrovascular, inflammatory, and neurodegenerative blood biomarkers as well as clinical and neuroimaging data

Key Dates

Start date
Nov 27, 2023
Status verified
Jul 2025
Primary completion
Jan 31, 2027
Completion
May 31, 2027

Study Design

Enrollment
300 participants (estimated)

Arms

  • Arm: TBI Group
    Participants in this group will have been identified as sustaining a traumatic brain injury (mild, moderate, severe, or penetrating).
  • Arm: High-blast exposed control group
    Participants in this group will have no history of traumatic brain injury AND will have a lifetime history of greater than 10 blast exposures.
  • Arm: Low-blast exposed control group
    Participants in this group will have no history of traumatic brain injury AND will have a lifetime history of less than 10 blast exposures.

Primary Outcome Measure

Panel of blood biomarkers [ Time Frame: 3 years ]

Central Contacts

Locations (1)

FacilityCityStateZIPSite coordinators
Walter Reed National Military Medical CenterBethesdaMaryland20889
Sara Lippa, PhD

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